Therapy Detail
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| Therapy Name | alphaDC1 + NK-like CTLs |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| NK-like CTLs | autologous NK-like CTLs|autologous aDC1-induced CTLs | NK-like CTLs (nCTLs) are autologous T-lymphocytes that are treated with autologous alpha-type-1 dendritic cells that have been exposed to patient-specific tumor antigens, which potentially results in natural killer-like activity and increased tumor cell lysis (NCI Drug Dictionary). | ||
| alphaDC1 | alpha-type-1-polarized DC|Alpha-type-1 Polarized Dendritic Cells | alphaDC1 is a polarized DC1 vaccine comprising autologous dendritic cells that is matured by treating with chemokines, potentially resulting in enhanced cytokine production and anti-tumor immune response against tumor cells (PMID: 15342370). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03735589 | Phase Ib/II | alphaDC1 + NK-like CTLs | Specialized Immune Cells (nCTLs) and a Vaccine (Alpha-type-1 Polarized Dendritic Cells) in Treating Patients With Stage II-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer | Withdrawn | USA | 0 |
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