Therapy Detail
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| Therapy Name | INBRX-106 |
| Synonyms | |
| Therapy Description |
INBRX-106 (ES 102) is a hexavalent antibody that binds to the TNFRSF4 (OX40) receptor, resulting in clustering and activation of TNFRSF4 (OX40), and potentially leading to activation of immune response and tumor cell killing (NCI Drug Dictionary). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| INBRX-106 | INBRX106|INBRX 106|ES 102|ES-102|ES102 | OX40 Antibody 15 | INBRX-106 (ES 102) is a hexavalent antibody that binds to the TNFRSF4 (OX40) receptor, resulting in clustering and activation of TNFRSF4 (OX40), and potentially leading to activation of immune response and tumor cell killing (NCI Drug Dictionary). |
Filtering
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04198766 | Phase Ib/II | INBRX-106 INBRX-106 + Pembrolizumab Carboplatin + INBRX-106 + Nab-paclitaxel + Pembrolizumab Pembrolizumab Cisplatin + INBRX-106 + Pembrolizumab + Pemetrexed Disodium Carboplatin + INBRX-106 + Pembrolizumab + Pemetrexed Disodium | Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda) in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist) | Recruiting | USA | 3 |
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