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Therapy Detail

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Therapy Name CD4CAR
Synonyms
Therapy Description

CD4CAR is a third-generation chimeric antigen receptor that targets CD4 and contains domains, CD28 and 4-1BB, and the signaling domain, CD3zeta, which potentially enhances immune response and leads to lysis of CD4-expressing tumor cells (PMID: 29348865, PMID: 31413761).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
CD4CAR CD4CAR is a third-generation chimeric antigen receptor that targets CD4 and contains domains, CD28 and 4-1BB, and the signaling domain, CD3zeta, which potentially enhances immune response and leads to lysis of CD4-expressing tumor cells (PMID: 29348865, PMID: 31413761).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06197672 Phase I CD4CAR Chimeric Antigen Receptor T Cell Redirected to Target CD4 Positive Relapsed Refractory Acute Myeloid Leukemia (AML ) As a Bridge to Allogeneic Stem Cell Transplant Recruiting USA 0
NCT06071624 Phase I CD4CAR Chimeric Antigen Receptor T Cell Therapy Redirected to CD4 (CD4CAR)as a Second Line Treatment for Chronic Myelomonocytic Leukemia, CMML. Recruiting USA 0
NCT03829540 Phase I CD4CAR CD4CAR for CD4+ Leukemia and Lymphoma Recruiting USA 0


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