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Therapy Name PLX038
Synonyms
Therapy Description

PLX038 is a PEG-conjugated form of the topoisomerase inhibitor SN-38 (PMID: 31707444).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
PLX038 PLX038A|PLX-038|PLX 038 TOPO Inhibitor (Pan) 3 PLX038 is a PEG-conjugated form of the topoisomerase inhibitor SN-38 (PMID: 31707444).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ATM del prostate cancer sensitive PLX038 Preclinical - Cell line xenograft Actionable In a preclinical study, PLX038 resulted in inhibition of tumor growth and increased event-free survival in a cell line xenograft model of prostate cancer harboring ATM deletion (PMID: 35999657). 35999657

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06161519 Phase Ib/II PLX038 PLX038 in Primary Central Nervous System Tumors Containing MYC or MYCN Amplifications Recruiting USA 0
NCT05465941 Phase II PLX038 PLX038 for the Treatment of Patients With Platinum-resistant Ovarian, Primary Peritoneal, and Fallopian Tube Cancer Recruiting USA 0
NCT06162351 Phase II PLX038 A Study to Evaluate the Efficacy and Toxicities of PLX038, in Patients With Locally Advanced or Metastatic Triple-negative Breast Cancer (TOPOLOGY) Recruiting FRA 0
NCT02646852 Phase I PLX038 A Phase I Study of PLX038 in Patients With Advanced Solid Tumors Completed USA 0


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