Therapy Detail
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| Therapy Name | PLX038 |
| Synonyms | |
| Therapy Description |
PLX038 is a PEG-conjugated form of the topoisomerase inhibitor SN-38 (PMID: 31707444). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| PLX038 | PLX038A|PLX-038|PLX 038 | TOPO Inhibitor (Pan) 3 | PLX038 is a PEG-conjugated form of the topoisomerase inhibitor SN-38 (PMID: 31707444). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| ATM del | prostate cancer | sensitive | PLX038 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, PLX038 resulted in inhibition of tumor growth and increased event-free survival in a cell line xenograft model of prostate cancer harboring ATM deletion (PMID: 35999657). | 35999657 |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05465941 | Phase II | PLX038 | PLX038 for the Treatment of Patients With Platinum-resistant Ovarian, Primary Peritoneal, and Fallopian Tube Cancer | Recruiting | USA | 0 |
| NCT06162351 | Phase II | PLX038 | A Study to Evaluate the Efficacy and Toxicities of PLX038, in Patients With Locally Advanced or Metastatic Triple-negative Breast Cancer (TOPOLOGY) | Recruiting | FRA | 0 |
| NCT06161519 | Phase Ib/II | PLX038 | PLX038 in Primary Central Nervous System Tumors Containing MYC or MYCN Amplifications | Recruiting | USA | 0 |
| NCT02646852 | Phase I | PLX038 | A Phase I Study of PLX038 in Patients With Advanced Solid Tumors | Completed | USA | 0 |
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