Therapy Detail
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| Therapy Name | Danazol |
| Synonyms | |
| Therapy Description |
Danazol is an attenuated synthetic hormone that competitively binds to androgen receptors and reduces hormone synthesis, potentially inducing apoptosis and cytotoxicity of tumor cells (PMID: 26692089, PMID: 2486535). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Danazol | Anatrol | Hormone - Anti-androgens 57 | Danazol is an attenuated synthetic hormone that competitively binds to androgen receptors and reduces hormone synthesis, potentially inducing apoptosis and cytotoxicity of tumor cells (PMID: 26692089, PMID: 2486535). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04173494 | Phase III | Danazol Momelotinib | A Study of Momelotinib Versus Danazol in Symptomatic and Anemic Myelofibrosis Patients (MOMENTUM) | Completed | USA | SWE | ROU | POL | NZL | ITA | ISR | HUN | GBR | FRA | ESP | DNK | DEU | CZE | CAN | BGR | BEL | AUT | AUS | 3 |
| NCT03165734 | Phase III | Ruxolitinib Hydroxyurea Pacritinib Danazol | A Phase 3 Study of Pacritinib in Patients with Primary Myelofibrosis, Post Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis (PACIFICA) | Recruiting | USA | ROU | POL | ITA | ISR | HUN | GBR | FRA | ESP | DEU | CZE | CAN | BGR | AUS | 9 |
| NCT04576156 | Phase III | Thalidomide Danazol Hydroxyurea Imetelstat | A Study Comparing Imetelstat Versus Best Available Therapy for the Treatment of Intermediate-2 or High-risk Myelofibrosis (MF) Who Have Not Responded to Janus Kinase (JAK)-Inhibitor Treatment | Recruiting | USA | TUR | POL | ITA | ISR | HUN | GBR | FRA | ESP | DNK | DEU | BRA | BGR | BEL | AUT | AUS | ARG | 9 |
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