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Therapy Detail
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| Therapy Name | Izuralimab |
| Synonyms | |
| Therapy Description |
Izuralimab (XmAb23104) is a bispecific antibody that binds to PD-1 (PDCD1) and ICOS (inducible T-cell costimulator, CD278), potentially resulting in enhanced anti-tumor immune response (Cancer Res 2018;78(13 Suppl):Abstract nr 2784). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Izuralimab | XmAb 23104|XmAb23104 | PD-L1/PD-1 antibody 124 | Izuralimab (XmAb23104) is a bispecific antibody that binds to PD-1 (PDCD1) and ICOS (inducible T-cell costimulator, CD278), potentially resulting in enhanced anti-tumor immune response (Cancer Res 2018;78(13 Suppl):Abstract nr 2784). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03752398 | Phase I | Izuralimab | A Study of XmAb23104 in Subjects With Selected Advanced Solid Tumors (DUET-3) (DUET-3) | Completed | USA | 0 |
| NCT05879185 | Phase II | Izuralimab | A Study of XmAb23104 in People With Sarcoma | Terminated | USA | 0 |
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