Therapy Detail
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| Therapy Name | GGTI-2418 |
| Synonyms | |
| Therapy Description |
GGTI-2418 is a selective inhibitor of GGTase I, leading to inhibition of protein geranylgeranylation, cell cycle arrest, and potentially inhibition of tumor growth (PMID: 19204084). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| GGTI-2418 | PTX-100 | GGTI-2418 is a selective inhibitor of GGTase I, leading to inhibition of protein geranylgeranylation, cell cycle arrest, and potentially inhibition of tumor growth (PMID: 19204084). |
Filtering
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- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
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- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03900442 | Phase I | GGTI-2418 | Phase 1 Study of PTX-100 in Patients With Advanced Malignancies | Completed | AUS | 0 |
| NCT06854653 | Phase II | GGTI-2418 | A Phase 2 Study of PTX 100 in Patients With Relapsed/Refractory CTCL | Recruiting | USA | ITA | FRA | AUS | 0 |
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