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Therapy Detail
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| Therapy Name | INVAC-1 |
| Synonyms | |
| Therapy Description |
INVAC-1 is a cancer vaccine comprised of a DNA plasmid engineered to encode a catalytically inactive human TERT (hTERT) linked to ubiquitin for rapid proteosomal degradation, which potentially induces an anti-tumor immune response and cytotoxicity against TERT-expressing cancer cells and delays tumor growth (PMID: 27141336, PMID: 31558479). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| INVAC-1 | INVAC-1 is a cancer vaccine comprised of a DNA plasmid engineered to encode a catalytically inactive human TERT (hTERT) linked to ubiquitin for rapid proteosomal degradation, which potentially induces an anti-tumor immune response and cytotoxicity against TERT-expressing cancer cells and delays tumor growth (PMID: 27141336, PMID: 31558479). |
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03265717 | Phase II | INVAC-1 | DNA Plasmid Encoding a Modified Human Telomerase Reverse Transcriptase (hTERT), Invac-1 in Chronic Lymphocytic Leukemia | Terminated | USA | 0 |
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