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Therapy Name JNJ-74699157
Synonyms
Therapy Description

JNJ-74699157 binds to and inhibits GDP-bound KRAS G12C, resulting in decreased downstream signaling and potentially inhibiting tumor growth (PMID: 32014824).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
JNJ-74699157 JNJ 74699157|JNJ74699157|ARS3248|ARS 3248|ARS-3248 KRAS G12C inhibitor 34 JNJ-74699157 binds to and inhibits GDP-bound KRAS G12C, resulting in decreased downstream signaling and potentially inhibiting tumor growth (PMID: 32014824).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04006301 Phase I JNJ-74699157 First-in-Human Study of JNJ-74699157 in Participants With Tumors Harboring the KRAS G12C Mutation Completed USA | FRA 0


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