Therapy Detail
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| Therapy Name | Lenalidomide + Montanide ISA 51 + Sargramostim + SurVaxM |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Lenalidomide | Revlimid | IMiD-1 | Revlimid (lenalidomide) is a thalidomide analog which regulates cytokine production and stimulates T cells and NK cells activity (PMID: 24328678). Revlimid (lenalidomide) is FDA approved for use in multiple myeloma, relapsed or refractory Mantle cell lymphoma, and in combination with a rituximab product in follicular lymphoma and marginal zone lymphoma (FDA.gov). | |
| Montanide ISA 51 | ||||
| Sargramostim | Leukine | GM-CSF|Prokine | ||
| SurVaxM | SVN53-67/M57-KLH | SurVaxM (SVN53-67/M57-KLH) is a peptide vaccine targeting survivin (Birc5), which may induce anti-tumor immune response (PMID: 27576783). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT02334865 | Phase I | Lenalidomide + Montanide ISA 51 + Sargramostim + SurVaxM | SVN53-67/M57-KLH Peptide Vaccine in Treating Patients With Newly Diagnosed Multiple Myeloma Receiving Lenalidomide Maintenance Therapy | Active, not recruiting | USA | 0 |
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