Therapy Detail
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| Therapy Name | Anti-FLT3 CAR-T cells |
| Synonyms | |
| Therapy Description |
Anti-FLT3 CAR-T cells are autologous T-cells engineered to express a chimeric antigen receptor targeting FLT3, which potentially induces cytotoxic immune response against FLT3-expressing tumor cells (Journal of Clinical Oncology 2019 37:15_suppl, 7032, PMID: 32589753). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Anti-FLT3 CAR-T cells | AMG553|AMG-553 | Anti-FLT3 CAR-T cells are autologous T-cells engineered to express a chimeric antigen receptor targeting FLT3, which potentially induces cytotoxic immune response against FLT3-expressing tumor cells (Journal of Clinical Oncology 2019 37:15_suppl, 7032, PMID: 32589753). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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- Click on any column header arrows to sort by that column
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06786533 | Phase I | Cyclophosphamide + Fludarabine Anti-FLT3 CAR-T cells | Clinical Study of Anti-FLT3 CAR-T Cells for the Treatment of Relapsed/refractory AML | Recruiting | USA | 0 |
| NCT03904069 | Phase I | Anti-FLT3 CAR-T cells | Study Evaluating the Safety, Tolerability, and Efficacy of FLT3 CAR-T AMG 553 in FLT3-positive Relapsed/Refractory AML | Withdrawn | USA | 0 |
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