Therapy Detail

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Therapy Name Carboplatin + Durvalumab + Etoposide
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Carboplatin Paraplatin CBDCA Chemotherapy - Platinum 7 Paraplatin (carboplatin) is a second-generation platinum compound and is activated intracellularly to form reactive platinum complexes that cross link DNA with DNA and with proteins. This induces apoptosis and inhibits cell growth (NCI Drug Dictionary).
Durvalumab Imfinzi MEDI4736 Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 121 Imfinzi (durvalumab) is a monoclonal antibody that binds to and inhibits PD-L1 (CD274), potentially resulting in increased immune response to tumors (PMID: 25943534, PMID: 28214651). Imfinzi (durvalumab) is FDA-approved for use in patients with urothelial carcinoma and unresectable, stage III non-small cell lung cancer, in combination with Imjudo (tremelimumab) and platinum-based chemotherapy in patients with metastatic non-small cell lung cancer (NSCLC) without sensitizing EGFR or ALK mutations, in combination with platinum-based chemotherapy as neoadjuvant therapy followed by surgery and adjuvant Imfinzi (durvalumab) in patients with resectable non-small cell lung cancer, in combination with etoposide and carboplatin or cisplatin in patients with extensive stage small cell lung cancer, in combination with cisplatin and gemcitabine in patients with locally advanced or metastatic biliary tract cancer, in combination with Imjudo (tremelimumab) in adult patients with unresectable hepatocellular carcinoma, and in combination with carboplatin plus paclitaxel followed by single-agent Imfinzi (durvalumab) in adult patients with mismatch repair deficient endometrial cancer (FDA.gov).
Etoposide Vepesid EPEG|Eposin|VP-16|VP-16-213 TOPO2 inhibitor 5 Vepesid (etoposide) binds to and inhibits DNA topoisomerase II, resulting in accumulated DNA damage, inhibition of replication, and cell death (NCI Drug Dictionary).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05161533 Phase II Cisplatin + Durvalumab + Etoposide Carboplatin + Durvalumab + Etoposide Hypofractionated Radiation Therapy After Durvalumab and Chemotherapy for the Treatment of Stage IV Extensive Stage Small Cell Lung Cancer, CASPIAN-RT Trial Withdrawn USA 0
NCT04951115 Phase II Cisplatin + Durvalumab + Etoposide Carboplatin + Durvalumab + Etoposide A Trial With Chemotherapy, Immunotherapy, and Radiotherapy for Patients With Newly Diagnosed Stage IV Small Cell Lung Cancer Completed USA 0
NCT06464068 Phase II Cisplatin + Durvalumab + Etoposide Carboplatin + Durvalumab + Etoposide Durvalumab AGNOSTIC THERAPY IN A PHASE II SINGLE-ARM STUDY IN FIRST-LINE TREATMENT OF DURVALUMAB IN ASSOCIATION WITH CARBOPLATIN OR CISPLATIN AND ETOPOSIDE IN PATIENTS AFFECTED BY EXTENSIVE STAGE - EXTRAPULMONARY SMALL CELL CARCINOMA (DURVASCC) Recruiting ITA 0
NCT05068232 Phase II Carboplatin + Durvalumab + Etoposide Durvalumab Durvalumab and Ablative Radiation in Small Cell Lung Cancer (DARES) Recruiting USA 0
NCT04397003 Phase II Carboplatin + Durvalumab + Etoposide Durvalumab + Tremelimumab Durvalumab + Personalized cancer vaccine + Tremelimumab Personalized Neoantigen Vaccine in Combination With Durvalumab (MEDI4736) and Tremelimumab in Extensive Stage Small Cell Lung Cancer Recruiting USA 0
NCT05796089 Phase II Cisplatin + Durvalumab + Etoposide Carboplatin + Durvalumab + Etoposide Chemotherapy and Immunotherapy in Extensive-Stage Small-Cell Lung Cancer With Thoracic Radiotherapy (CHEST RT) Recruiting AUS 0
NCT04745689 Phase II AZD2811 + Durvalumab Cisplatin + Durvalumab + Etoposide Carboplatin + Durvalumab + Etoposide Study of AZD2811 + Durvalumab in ES-SCLC (TAZMAN) Active, not recruiting USA | POL | ESP 1
NCT05403723 Phase I Cisplatin + Durvalumab + Etoposide Carboplatin + Durvalumab + Etoposide Adaptive SBRT Plus Chemoimmunotherapy for ES-SCLC Suspended USA 0
NCT04774380 Phase III Cisplatin + Durvalumab + Etoposide Carboplatin + Durvalumab + Etoposide Study of Durvalumab in Combination With Platinum and Etoposide for the First Line Treatment of Patients With Extensive-stage Small Cell Lung Cancer (LUMINANCE) Active, not recruiting TUR | ITA | DEU | CZE | CAN | BGR 0
NCT06418087 Phase II Carboplatin + Durvalumab + Etoposide Durvalumab With Carboplatin and Etoposide Chemotherapy in Pulmonary Large-cell Neuroendocrine Carcinoma (LCNEC) (DUPLE) Recruiting ITA 0
NCT06223711 Phase II Durvalumab Cisplatin + Durvalumab + Etoposide Carboplatin + Durvalumab + Etoposide Durvalumab With Consolidative Radiochemotherapy and Ablative Stereotactic Radiotherapy in Oligometastatic ES-SCLC Recruiting DEU 0
NCT06393816 Phase II Cisplatin + Durvalumab + Etoposide Carboplatin + Durvalumab + Etoposide FIRST-NEC (GFPC 01-2022) - Combination of Durvalumab With Etoposide and Platinum (FIRST-NEC) Recruiting FRA 1
NCT03963414 Phase I Carboplatin + Durvalumab + Etoposide + Tremelimumab Carboplatin + Durvalumab + Etoposide A Study of Durvalumab Plus Tremelimumab With Chemotherapy in Untreated ES-SCLC Terminated USA 0


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