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Therapy Name KITE-439
Synonyms
Therapy Description

KITE-439 consists of autologous T-cells engineered to express a T-cell receptor that recognizes HLA-A*02:01-restricted human papillomavirus type 16 isoform E7 (HPV16 E7) protein, potentially resulting in antitumor activity of cells expressing HPV16 E7 (NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
KITE-439 KITE 439 KITE-439 consists of autologous T-cells engineered to express a T-cell receptor that recognizes HLA-A*02:01-restricted human papillomavirus type 16 isoform E7 (HPV16 E7) protein, potentially resulting in antitumor activity of cells expressing HPV16 E7 (NCI Drug Dictionary).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03912831 Phase I Cyclophosphamide + Fludarabine KITE-439 Safety and Efficacy of KITE-439 in HLA-A*02:01+ Adults With Relapsed/Refractory HPV16+ Cancers Terminated USA 0
NCT05041309 Phase II KITE-585 KITE-222 Brexucabtagene autoleucel KITE-718 axicabtagene ciloleucel KITE-439 Long-term Follow-up Study for Participants of Kite-Sponsored Interventional Studies Treated With Gene-Modified Cells Enrolling by invitation USA | NLD | ISR | GBR | FRA | DEU | CAN | AUS 1


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