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Therapy Name Anti-PSCA(dCH2)BBz-CAR-T cells
Synonyms
Therapy Description

Anti-PSCA(dCH2)BBz-CAR-T cells are T-cells engineered to express a PSCA-targeted chimeric antigen receptor (CAR) containing a TNFRSF9 (4-1BB) signaling domain and truncated CD19, which may induce killing of PSCA-expressing tumor cells and inhibit tumor growth (PMID: 29308300).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Anti-PSCA(dCH2)BBz-CAR-T cells anti-PSCA-CAR-4-1BB/TCRzeta-CD19t-expressing T lymphocytes Anti-PSCA(dCH2)BBz-CAR-T cells are T-cells engineered to express a PSCA-targeted chimeric antigen receptor (CAR) containing a TNFRSF9 (4-1BB) signaling domain and truncated CD19, which may induce killing of PSCA-expressing tumor cells and inhibit tumor growth (PMID: 29308300).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03873805 Phase I Cyclophosphamide + Fludarabine Anti-PSCA(dCH2)BBz-CAR-T cells PSCA-CAR T Cells in Treating Patients With PSCA+ Metastatic Castration Resistant Prostate Cancer Active, not recruiting USA 0
NCT05805371 Phase I Anti-PSCA(dCH2)BBz-CAR-T cells PSCA-Targeting CAR-T Cells Plus or Minus Radiation for the Treatment of Patients With PSCA+ Metastatic Castration-Resistant Prostate Cancer Recruiting USA 0


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