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Therapy Name INCB086550
Synonyms
Therapy Description

INCB086550 is a small molecule PD-L1 (CD274) inhibitor that prevents PD-L1/PD-1 interaction, potentially leading to enhanced anti-tumor immune response (PMID: 35254416).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
INCB086550 INCB 086550|INCB-086550 Immune Checkpoint Inhibitor 149 PD-L1 Inhibitor 14 INCB086550 is a small molecule PD-L1 (CD274) inhibitor that prevents PD-L1/PD-1 interaction, potentially leading to enhanced anti-tumor immune response (PMID: 35254416).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CD274 over exp breast cancer sensitive INCB086550 Preclinical - Cell line xenograft Actionable In a preclinical study, INCB086550 decreased CD274 (PD-L1) surface expression and tumor growth in a cell line xenograft model of breast cancer with high CD274 (PD-L1) expression (PMID: 35254416). 35254416
CD274 over exp colorectal cancer sensitive INCB086550 Preclinical Actionable In a preclinical study, INCB086550 decreased CD274 (PD-L1) cell surface expression and inhibited tumor growth in a mouse model of colorectal cancer with CD274 (PD-L1) overexpression (PMID: 35254416). 35254416

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03762447 Phase I INCB086550 A Study Exploring the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INCB086550 in Participants With Advanced Solid Tumors Completed USA | ITA | GBR | FRA | BEL 0


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