Therapy Detail
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| Therapy Name | EndoTAG-1 + Gemcitabine |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| EndoTAG-1 | LipoPac|MBT-0206|Cationic Liposome-Encapsulated Paclitaxel | EndoTAG-1 is comprised of paclitaxel encapsulated in cationic liposomes that preferentially targets endothelial cells, which inhibits microtubule disassembly, potentially leading to decreased cell proliferation and increased apoptosis (NCI Drug Dictionary). | ||
| Gemcitabine | Gemzar | Difluorodeoxycytidine Hydrochlorothiazide|LY-188011 | Chemotherapy - Antimetabolite 14 | Gemzar (gemcitabine) is converted in cells to difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP), which act to inhibit ribonucleoside reductase and as a deoxynucleotide analog respectively, resulting in DNA strand termination and apoptosis (NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03126435 | Phase III | EndoTAG-1 + Gemcitabine Gemcitabine | EndoTAG-1 Plus Gemcitabine Versus Gemcitabine Alone in Patients With Measurable Locally Advanced and/or Metastatic Adenocarcinoma of the Pancreas Failed on FOLFIRINOX Treatment | Completed | USA | ISR | HUN | FRA | 3 |
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