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| Therapy Name | BI 905677 |
| Synonyms | |
| Therapy Description |
BI 905677 is an antagonistic antibody that binds to LRP5 and LRP6 and inhibits Wnt signaling, potentially resulting in anti-tumor activity (PMID: 39617530, Cancer Res 2019;79(13 Suppl):Abstract nr DDT01-01). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| BI 905677 | BI-905677|BI905677|Anti-LRP5/6 Nanobody BI 905677 | WNT Inhibitor 17 | BI 905677 is an antagonistic antibody that binds to LRP5 and LRP6 and inhibits Wnt signaling, potentially resulting in anti-tumor activity (PMID: 39617530, Cancer Res 2019;79(13 Suppl):Abstract nr DDT01-01). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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- Click on any column header arrows to sort by that column
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03604445 | Phase I | BI 905677 | This Study Aims to Find and Test a Safe Dose of BI 905677 in Patients With Different Types of Cancer (Solid Tumours) | Terminated | USA | NLD | ESP | 1 |
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