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Therapy Name Tempol
Synonyms
Therapy Description

Tempol is a heterocyclic nitroxide free radical that induces cellular oxidative stress, and may inhibit the activity of Idh1 and Idh2, induce tumor cell death, and inhibit tumor cell proliferation (PMID: 32366855, PMID: 11033415).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Tempol MTS-01|MBM-02|Piperidine Nitroxide Tempol is a heterocyclic nitroxide free radical that induces cellular oxidative stress, and may inhibit the activity of Idh1 and Idh2, induce tumor cell death, and inhibit tumor cell proliferation (PMID: 32366855, PMID: 11033415).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05491928 Expanded access Tempol Treatment of Metastatic Cancer in Terminally Diagnosed Patients Available USA 0
NCT04874506 Phase II Tempol MBM-02 (Tempol) for the Treatment of Glioblastoma Multiforme (GBM) Unknown status USA 0
NCT04337099 Expanded access Tempol A Single Patient Compassionate Use of MBM-02 (Tempol) for the Treatment of Prostate Cancer Available USA 0
NCT04876755 Phase II Tempol MBM-02 (Tempol) for the Treatment of Biochemical Recurrent Prostate Cancer Unknown status USA 0


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