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Therapy Name ONCR-177
Synonyms
Therapy Description

ONCR-177 is an oncolytic herpes simplex virus (HSV) engineered to express PD-1 and CTLA-4 antagonists, IL-12, CCL4, and the extracellular domain of FLT3LG, and to contain a microRNA-binding cassette that potentially allows selective HSV replication in tumor cells, which may enhance anti-tumor immune response and induce tumor cell killing (Cancer Res 2019;79(13 Suppl):Abstract nr 1455).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
ONCR-177 ONCR177|ONCR 177 CTLA4 Inhibitor 4 ONCR-177 is an oncolytic herpes simplex virus (HSV) engineered to express PD-1 and CTLA-4 antagonists, IL-12, CCL4, and the extracellular domain of FLT3LG, and to contain a microRNA-binding cassette that potentially allows selective HSV replication in tumor cells, which may enhance anti-tumor immune response and induce tumor cell killing (Cancer Res 2019;79(13 Suppl):Abstract nr 1455).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04348916 Phase I ONCR-177 + Pembrolizumab ONCR-177 Study of ONCR-177 Alone and in Combination With PD-1 Blockade in Adult Subjects With Advanced and/or Refractory Cutaneous, Subcutaneous or Metastatic Nodal Solid Tumors Terminated USA | CAN 0


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