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Therapy Name TPST-1495
Synonyms
Therapy Description

TPST-1495 is a dual antagonist that selectively inhibits EP2 and EP4, and reverses Prostaglandin E2 mediated immune suppression, potentially resulting in enhanced antitumor immune response and tumor growth inhibition (Journal for ImmunoTherapy of Cancer 2019;7:282, Abs nr: P311).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
TPST-1495 TPST1495|TPST 1495 TPST-1495 is a dual antagonist that selectively inhibits EP2 and EP4, and reverses Prostaglandin E2 mediated immune suppression, potentially resulting in enhanced antitumor immune response and tumor growth inhibition (Journal for ImmunoTherapy of Cancer 2019;7:282, Abs nr: P311).

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04344795 Phase I TPST-1495 Pembrolizumab + TPST-1495 Phase 1a/1b Study of TPST-1495 Alone and With Pembrolizumab in Subjects With Solid Tumors Active, not recruiting USA 0
NCT06129604 Phase II TPST-1495 Pilot Window of Opportunity Trial (POET) Recruiting USA 0


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