Therapy Detail
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| Therapy Name | Vistusertib |
| Synonyms | |
| Therapy Description |
Vistusertib (AZD2014) is an ATP-competitive inhibitor of mTOR, which may result in tumor growth inhibition (PMID: 23375793, PMID: 31707687). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Vistusertib | AZD2014|AZD-2014 | mTOR Inhibitor 51 | Vistusertib (AZD2014) is an ATP-competitive inhibitor of mTOR, which may result in tumor growth inhibition (PMID: 23375793, PMID: 31707687). |
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- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03071874 | Phase II | Vistusertib | Phase II Study Of Vistusertib (AZD2014) For Recurrent Grade II-III Meningiomas | Unknown status | USA | 0 |
| NCT02619864 | Phase Ib/II | Vistusertib | mTORC1/mTORC2 Kinase Inhibitor AZD2014 in Previously Treated Glioblastoma Multiforme | Completed | CAN | 0 |
| NCT02403895 | Phase II | Vistusertib Paclitaxel | AZD2014 and Weekly Paclitaxel in Squamous NSCLC | Terminated | USA | ESP | DEU | 0 |
| NCT02813135 | Phase Ib/II | Lirilumab + Nivolumab Irinotecan + Olaparib Ceralasertib + Olaparib Futibatinib Vistusertib Cyclophosphamide + Nivolumab Ribociclib + Temozolomide + Topotecan Temozolomide + Topotecan + Vistusertib Adavosertib + Carboplatin CYC065 + Temozolomide CYC065 + Cytarabine Capmatinib + Everolimus Enasidenib Everolimus + Ribociclib Selumetinib + Vistusertib Avelumab + Peposertib + Temozolomide Capivasertib + Vinorelbine Dexamethasone + Everolimus + Ribociclib | European Proof-of-Concept Therapeutic Stratification Trial of Molecular Anomalies in Relapsed or Refractory Tumors (ESMART) | Recruiting | NLD | ITA | GBR | FRA | ESP | DNK | 0 |
| NCT02831257 | Phase II | Vistusertib | AZD2014 In NF2 Patients With Progressive or Symptomatic Meningiomas | Completed | USA | 0 |
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