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| NCT ID | NCT01217437 |
| Title | Temozolomide and Irinotecan Hydrochloride With or Without Bevacizumab in Treating Young Patients With Recurrent or Refractory Medulloblastoma or CNS Primitive Neuroectodermal Tumors |
| Recruitment | Completed |
| Gender | both |
| Phase | Phase II |
| Variant Requirements | No |
| Sponsors | National Cancer Institute (NCI) |
| Indications | |
| Therapies | |
| Age Groups: | adult | child |
| Covered Countries | USA | NZL | CAN | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| AdventHealth Orlando | Orlando | Florida | 32803 | United States | Details | |
| Advocate Children's Hospital-Oak Lawn | Oak Lawn | Illinois | 60453 | United States | Details | |
| Albany Medical Center | Albany | New York | 12208 | United States | Details | |
| Alberta Children's Hospital | Calgary | Alberta | T3B 6A8 | Canada | Details | |
| Alfred I duPont Hospital for Children | Wilmington | Delaware | 19803 | United States | Details | |
| Alliance for Childhood Diseases/Cure 4 the Kids Foundation | Las Vegas | Nevada | 89135 | United States | Details | |
| Arkansas Children's Hospital | Little Rock | Arkansas | 72202-3591 | United States | Details | |
| Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center | Houston | Texas | 77030 | United States | Details | |
| BI-LO Charities Children's Cancer Center | Greenville | South Carolina | 29605 | United States | Details | |
| Blank Children's Hospital | Des Moines | Iowa | 50309 | United States | Details | |
| British Columbia Children's Hospital | Vancouver | British Columbia | V6H 3V4 | Canada | Details | |
| Bronson Methodist Hospital | Kalamazoo | Michigan | 49007 | United States | Details | |
| Brooke Army Medical Center | Fort Sam Houston | Texas | 78234 | United States | Details | |
| C S Mott Children's Hospital | Ann Arbor | Michigan | 48109 | United States | Details | |
| CancerCare Manitoba | Winnipeg | Manitoba | R3E 0V9 | Canada | Details | |
| Cardinal Glennon Children's Medical Center | Saint Louis | Missouri | 63104 | United States | Details | |
| Carolinas Medical Center/Levine Cancer Institute | Charlotte | North Carolina | 28203 | United States | Details | |
| Cedars Sinai Medical Center | Los Angeles | California | 90048 | United States | Details | |
| Centre Hospitalier Universitaire de Quebec | Quebec | G1V 4G2 | Canada | Details | ||
| Centre Hospitalier Universitaire Sainte-Justine | Montreal | Quebec | H3T 1C5 | Canada | Details | |
| Children's Healthcare of Atlanta - Egleston | Atlanta | Georgia | 30322 | United States | Details | |
| Children's Hospital Los Angeles | Los Angeles | California | 90027 | United States | Details | |
| Children's Hospital Medical Center of Akron | Akron | Ohio | 44308 | United States | Details | |
| Children's Hospital New Orleans | New Orleans | Louisiana | 70118 | United States | Details | |
| Children's Hospital of Alabama | Birmingham | Alabama | 35233 | United States | Details | |
| Children's Hospital of Eastern Ontario | Ottawa | Ontario | K1H 8L1 | Canada | Details | |
| Children's Hospital of Orange County | Orange | California | 92868 | United States | Details | |
| Children's Hospital of Philadelphia | Philadelphia | Pennsylvania | 19104 | United States | Details | |
| Children's Hospital of Pittsburgh of UPMC | Pittsburgh | Pennsylvania | 15224 | United States | Details | |
| Children's Hospital of The King's Daughters | Norfolk | Virginia | 23507 | United States | Details | |
| Children's Hospital of Wisconsin | Milwaukee | Wisconsin | 53226 | United States | Details | |
| Children's Hospitals and Clinics of Minnesota - Minneapolis | Minneapolis | Minnesota | 55404 | United States | Details | |
| Children's Mercy Hospitals and Clinics | Kansas City | Missouri | 64108 | United States | Details | |
| Children's National Medical Center | Washington | District of Columbia | 20010 | United States | Details | |
| Christchurch Hospital | Christchurch | 8011 | New Zealand | Details | ||
| Cincinnati Children's Hospital Medical Center | Cincinnati | Ohio | 45229 | United States | Details | |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | United States | Details | |
| Columbia Regional | Columbia | Missouri | 65201 | United States | Details | |
| Connecticut Children's Medical Center | Hartford | Connecticut | 06106 | United States | Details | |
| Cook Children's Medical Center | Fort Worth | Texas | 76104 | United States | Details | |
| Covenant Children's Hospital | Lubbock | Texas | 79410 | United States | Details | |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02215 | United States | Details | |
| Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | United States | Details | |
| Dayton Children's Hospital | Dayton | Ohio | 45404 | United States | Details | |
| Dell Children's Medical Center of Central Texas | Austin | Texas | 78723 | United States | Details | |
| Driscoll Children's Hospital | Corpus Christi | Texas | 78411 | United States | Details | |
| East Tennessee Childrens Hospital | Knoxville | Tennessee | 37916 | United States | Details | |
| El Paso Children's Hospital | El Paso | Texas | 79905 | United States | Details | |
| Geisinger Medical Center | Danville | Pennsylvania | 17822 | United States | Details | |
| Golisano Children's Hospital of Southwest Florida | Fort Myers | Florida | 33908 | United States | Details | |
| Greenville Cancer Treatment Center | Greenville | South Carolina | 29605 | United States | Details | |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | United States | Details | |
| Hospital for Sick Children | Toronto | Ontario | M5G 1X8 | Canada | Details | |
| IWK Health Centre | Halifax | Nova Scotia | B3K 6R8 | Canada | Details | |
| John Hunter Children's Hospital | Hunter Regional Mail Centre | New South Wales | 2310 | Australia | Details | |
| Johns Hopkins All Children's Hospital | Saint Petersburg | Florida | 33701 | United States | Details | |
| Johns Hopkins University/Sidney Kimmel Cancer Center | Baltimore | Maryland | 21287 | United States | Details | |
| Kaiser Permanente Downey Medical Center | Downey | California | 90242 | United States | Details | |
| Kaiser Permanente-Oakland | Oakland | California | 94611 | United States | Details | |
| Kapiolani Medical Center for Women and Children | Honolulu | Hawaii | 96826 | United States | Details | |
| Kingston Health Sciences Centre | Kingston | Ontario | K7L 2V7 | Canada | Details | |
| Laura and Isaac Perlmutter Cancer Center at NYU Langone | New York | New York | 10016 | United States | Details | |
| Lee Memorial Health System | Fort Myers | Florida | 33901 | United States | Details | |
| Legacy Emanuel Children's Hospital | Portland | Oregon | 97227 | United States | Details | |
| Legacy Emanuel Hospital and Health Center | Portland | Oregon | 97227 | United States | Details | |
| Loma Linda University Medical Center | Loma Linda | California | 92354 | United States | Details | |
| Lucile Packard Children's Hospital Stanford University | Palo Alto | California | 94304 | United States | Details | |
| Lurie Children's Hospital-Chicago | Chicago | Illinois | 60611 | United States | Details | |
| Marshfield Medical Center-Marshfield | Marshfield | Wisconsin | 54449 | United States | Details | |
| Mayo Clinic in Rochester | Rochester | Minnesota | 55905 | United States | Details | |
| McMaster Children's Hospital at Hamilton Health Sciences | Hamilton | Ontario | L8N 3Z5 | Canada | Details | |
| Medical City Dallas Hospital | Dallas | Texas | 75230 | United States | Details | |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | United States | Details | |
| MedStar Georgetown University Hospital | Washington | District of Columbia | 20007 | United States | Details | |
| Memorial Health University Medical Center | Savannah | Georgia | 31404 | United States | Details | |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | United States | Details | |
| Mercy Hospital Saint Louis | Saint Louis | Missouri | 63141 | United States | Details | |
| Methodist Children's Hospital of South Texas | San Antonio | Texas | 78229 | United States | Details | |
| Michigan State University Clinical Center | East Lansing | Michigan | 48824-7016 | United States | Details | |
| Miller Children's and Women's Hospital Long Beach | Long Beach | California | 90806 | United States | Details | |
| Montefiore Medical Center - Moses Campus | Bronx | New York | 10467 | United States | Details | |
| Morristown Medical Center | Morristown | New Jersey | 07960 | United States | Details | |
| Nationwide Children's Hospital | Columbus | Ohio | 43205 | United States | Details | |
| Nemours Children's Clinic - Orlando | Orlando | Florida | 32806 | United States | Details | |
| Nemours Children's Clinic - Pensacola | Pensacola | Florida | 32504 | United States | Details | |
| Nemours Children's Clinic-Jacksonville | Jacksonville | Florida | 32207 | United States | Details | |
| Nemours Children's Hospital | Orlando | Florida | 32827 | United States | Details | |
| Nevada Cancer Research Foundation NCORP | Las Vegas | Nevada | 89169 | United States | Details | |
| New York Medical College | Valhalla | New York | 10595 | United States | Details | |
| Newark Beth Israel Medical Center | Newark | New Jersey | 07112 | United States | Details | |
| Norton Children's Hospital | Louisville | Kentucky | 40202 | United States | Details | |
| Novant Health Presbyterian Medical Center | Charlotte | North Carolina | 28204 | United States | Details | |
| NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center | New York | New York | 10032 | United States | Details | |
| Oregon Health and Science University | Portland | Oregon | 97239 | United States | Details | |
| Orlando Health Cancer Institute | Orlando | Florida | 32806 | United States | Details | |
| Overlook Hospital | Summit | New Jersey | 07902 | United States | Details | |
| Penn State Children's Hospital | Hershey | Pennsylvania | 17033 | United States | Details | |
| Phoenix Childrens Hospital | Phoenix | Arizona | 85016 | United States | Details | |
| Primary Children's Hospital | Salt Lake City | Utah | 84113 | United States | Details | |
| Princess Margaret Hospital for Children | Perth | Western Australia | 6008 | Australia | Details | |
| Prisma Health Richland Hospital | Columbia | South Carolina | 29203 | United States | Details | |
| Providence Sacred Heart Medical Center and Children's Hospital | Spokane | Washington | 99204 | United States | Details | |
| Queensland Children's Hospital | South Brisbane | Queensland | 4101 | Australia | Details | |
| Rady Children's Hospital - San Diego | San Diego | California | 92123 | United States | Details | |
| Rainbow Babies and Childrens Hospital | Cleveland | Ohio | 44106 | United States | Details | |
| Rhode Island Hospital | Providence | Rhode Island | 02903 | United States | Details | |
| Riley Hospital for Children | Indianapolis | Indiana | 46202 | United States | Details | |
| Roswell Park Cancer Institute | Buffalo | New York | 14263 | United States | Details | |
| Royal Brisbane and Women's Hospital | Herston | Queensland | 4029 | Australia | Details | |
| Royal Children's Hospital-Brisbane | Herston | Queensland | 4029 | Australia | Details | |
| Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital | New Brunswick | New Jersey | 08903 | United States | Details | |
| Saint Barnabas Medical Center | Livingston | New Jersey | 07039 | United States | Details | |
| Saint Joseph's Hospital/Children's Hospital-Tampa | Tampa | Florida | 33607 | United States | Details | |
| Saint Jude Midwest Affiliate | Peoria | Illinois | 61637 | United States | Details | |
| Saint Luke's Cancer Institute - Boise | Boise | Idaho | 83712 | United States | Details | |
| Saint Mary's Hospital | West Palm Beach | Florida | 33407 | United States | Details | |
| Saint Peter's University Hospital | New Brunswick | New Jersey | 08901 | United States | Details | |
| Sanford Broadway Medical Center | Fargo | North Dakota | 58122 | United States | Details | |
| Saskatoon Cancer Centre | Saskatoon | Saskatchewan | S7N 4H4 | Canada | Details | |
| Seattle Children's Hospital | Seattle | Washington | 98105 | United States | Details | |
| Starship Children's Hospital | Grafton | Auckland | 1145 | New Zealand | Details | |
| State University of New York Upstate Medical University | Syracuse | New York | 13210 | United States | Details | |
| Summerlin Hospital Medical Center | Las Vegas | Nevada | 89144 | United States | Details | |
| Sunrise Hospital and Medical Center | Las Vegas | Nevada | 89109 | United States | Details | |
| Sutter Medical Center Sacramento | Sacramento | California | 95816 | United States | Details | |
| Sydney Children's Hospital | Randwick | New South Wales | 2031 | Australia | Details | |
| The Children's Hospital at Westmead | Westmead | New South Wales | 2145 | Australia | Details | |
| The Montreal Children's Hospital of the MUHC | Montreal | Quebec | H3H 1P3 | Canada | Details | |
| The Steven and Alexandra Cohen Children's Medical Center of New York | New Hyde Park | New York | 11040 | United States | Details | |
| Tulane University Health Sciences Center | New Orleans | Louisiana | 70112 | United States | Details | |
| UCSF Medical Center-Mission Bay | San Francisco | California | 94158 | United States | Details | |
| UCSF Medical Center-Parnassus | San Francisco | California | 94143 | United States | Details | |
| UNC Lineberger Comprehensive Cancer Center | Chapel Hill | North Carolina | 27599 | United States | Details | |
| University Medical Center of Southern Nevada | Las Vegas | Nevada | 89102 | United States | Details | |
| University of Alabama at Birmingham Cancer Center | Birmingham | Alabama | 35233 | United States | Details | |
| University of Arkansas for Medical Sciences | Little Rock | Arkansas | 72205 | United States | Details | |
| University of California Davis Comprehensive Cancer Center | Sacramento | California | 95817 | United States | Details | |
| University of Chicago Comprehensive Cancer Center | Chicago | Illinois | 60637 | United States | Details | |
| University of Florida Health Science Center - Gainesville | Gainesville | Florida | 32610 | United States | Details | |
| University of Hawaii Cancer Center | Honolulu | Hawaii | 96813 | United States | Details | |
| University of Illinois | Chicago | Illinois | 60612 | United States | Details | |
| University of Kentucky/Markey Cancer Center | Lexington | Kentucky | 40536 | United States | Details | |
| University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami | Florida | 33136 | United States | Details | |
| University of Minnesota/Masonic Cancer Center | Minneapolis | Minnesota | 55455 | United States | Details | |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216 | United States | Details | |
| University of New Mexico Cancer Center | Albuquerque | New Mexico | 87102 | United States | Details | |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | United States | Details | |
| University of Rochester | Rochester | New York | 14642 | United States | Details | |
| University of Vermont and State Agricultural College | Burlington | Vermont | 05405 | United States | Details | |
| University of Wisconsin Hospital and Clinics | Madison | Wisconsin | 53792 | United States | Details | |
| University Pediatric Hospital | San Juan | 00926 | Puerto Rico | Details | ||
| UT Southwestern/Simmons Cancer Center-Dallas | Dallas | Texas | 75390 | United States | Details | |
| Valley Children's Hospital | Madera | California | 93636 | United States | Details | |
| Vanderbilt University/Ingram Cancer Center | Nashville | Tennessee | 37232 | United States | Details | |
| Virginia Commonwealth University/Massey Cancer Center | Richmond | Virginia | 23298 | United States | Details | |
| Walter Reed National Military Medical Center | Bethesda | Maryland | 20889-5600 | United States | Details | |
| Washington University School of Medicine | Saint Louis | Missouri | 63110 | United States | Details | |
| Wayne State University/Karmanos Cancer Institute | Detroit | Michigan | 48201 | United States | Details |
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