Therapy Detail
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| Therapy Name | Irinotecan + Temozolomide |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Irinotecan | Camptosar | CPT-11 | TOPO1 inhibitor 11 | Camptosar (irinotecan) inhibits Topoisomerase-I activity, resulting in inhibition of DNA replication, and potentially leading to cell death and is indicated as a component of first-line therapy in combination with 5-fluorouracil and leucovorin for patients with metastatic or recurrent colorectal carcinoma (FDA.gov). |
| Temozolomide | Temodar | Methazolastone|TMZ | Chemotherapy - Alkylating 18 | Temodar (temozolomide) is a dacarbazine analog and cytotoxic alkylating agent (NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT01767194 | Phase II | Dinutuximab Temsirolimus Irinotecan + Temozolomide | Irinotecan Hydrochloride and Temozolomide With Temsirolimus or Monoclonal Antibody Ch14.18 in Treating Younger Patients With Refractory or Relapsed Neuroblastoma | Completed | USA | NZL | CAN | AUS | 1 |
| NCT03495921 | Phase III | FANG vaccine + Irinotecan + Temozolomide Irinotecan + Temozolomide | Vigil + Irinotecan and Temozolomide in Ewing's Sarcoma (VITA) | Terminated | USA | 0 |
| NCT04901702 | Phase Ib/II | Irinotecan + Temozolomide Irinotecan + Talazoparib | Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma | Active, not recruiting | USA | CAN | 0 |
| NCT05440786 | Phase II | Irinotecan + Temozolomide Abemaciclib + Irinotecan + Temozolomide | CAMPFIRE: A Study of Abemaciclib (LY2835219) in Participants With Ewing's Sarcoma | Recruiting | USA | ITA | FRA | ESP | DEU | AUS | 1 |
| NCT05999994 | Phase II | Docetaxel + Gemcitabine + Ramucirumab Cyclophosphamide + Ramucirumab + Vinorelbine Cyclophosphamide + Vinorelbine Irinotecan + Temozolomide Abemaciclib + Irinotecan + Temozolomide Docetaxel + Gemcitabine | A Master Protocol (LY900023) That Includes Several Clinical Trials of Drugs for Children and Young Adults With Cancer (CAMPFIRE) | Recruiting | USA | ITA | GBR | FRA | ESP | DEU | BEL | AUS | 1 |
| NCT02308527 | Phase II | Bevacizumab + Irinotecan + Temozolomide Temozolomide + Topotecan Bevacizumab + Temozolomide Bevacizumab + Temozolomide + Topotecan Dinutuximab beta + Temozolomide Temozolomide Dinutuximab beta + Temozolomide + Topotecan Irinotecan + Temozolomide Cyclophosphamide + Dinutuximab beta + Topotecan | Activity Study of Bevacizumab With Temozolomide ± Irinotecan for Neuroblastoma in Children (BEACON) | Active, not recruiting | NLD | ITA | IRL | GBR | FRA | ESP | DNK | CHE | BEL | AUT | 0 |
| NCT01217437 | Phase II | Irinotecan + Temozolomide Bevacizumab + Irinotecan + Temozolomide | Temozolomide and Irinotecan Hydrochloride With or Without Bevacizumab in Treating Young Patients With Recurrent or Refractory Medulloblastoma or CNS Primitive Neuroectodermal Tumors | Completed | USA | NZL | CAN | AUS | 1 |
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