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| NCT ID | NCT02741570 |
| Title | Study of Nivolumab in Combination With Ipilimumab Compared to the Standard of Care (Extreme Study Regimen) as First Line Treatment in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck |
| Acronym | CheckMate 651 |
| Recruitment | Completed |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Bristol-Myers Squibb |
| Indications | |
| Therapies | |
| Age Groups: | adult |
| Covered Countries | USA | POL | ITA | ISR | IRL | GRC | GBR | FRA | ESP | DEU | CHE | BRA | AUT | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Aorn Dei Colli | Napoli | 80131 | Italy | Details | ||
| Azienda Ospedaliera Di Perugia | Perugia | 06132 | Italy | Details | ||
| Azienda Ospedaliera Universitaria Di Modena | Modena | 41124 | Italy | Details | ||
| Fondazione Policlinico Universitario A. Gemelli | Roma | 00168 | Italy | Details | ||
| IRST Meldola | Meldola (fc) | 47014 | Italy | Details | ||
| Istituto Nazionale Tumori Fondazione Pascale | Napoli | 80131 | Italy | Details | ||
| Local Institution | Paris | 75908 | France | Details | ||
| Local Institution | Shimotsuke-shi | Tochigi | 3290498 | Japan | Details | |
| Local Institution - 0001 | Boston | Massachusetts | 02215 | United States | Details | |
| Local Institution - 0003 | Charlottesville | Virginia | 22908 | United States | Details | |
| Local Institution - 0004 | Ann Arbor | Michigan | 48109 | United States | Details | |
| Local Institution - 0005 | Stanford | California | 94305 | United States | Details | |
| Local Institution - 0006 | Chicago | Illinois | 60637 | United States | Details | |
| Local Institution - 0007 | Columbus | Ohio | 43210 | United States | Details | |
| Local Institution - 0008 | Tampa | Florida | 33612 | United States | Details | |
| Local Institution - 0009 | Houston | Texas | 77030 | United States | Details | |
| Local Institution - 0010 | Langhorne | Pennsylvania | 19047 | United States | Details | |
| Local Institution - 0011 | Fairfax | Virginia | 22301 | United States | Details | |
| Local Institution - 0012 | Charlotte | North Carolina | 28204 | United States | Details | |
| Local Institution - 0013 | Pittsburgh | Pennsylvania | 15232 | United States | Details | |
| Local Institution - 0014 | Houston | Texas | 77030 | United States | Details | |
| Local Institution - 0015 | Philadelphia | Pennsylvania | 19107 | United States | Details | |
| Local Institution - 0017 | Nea Kifissia | 14564 | Greece | Details | ||
| Local Institution - 0018 | Athens | 15123 | Greece | Details | ||
| Local Institution - 0019 | St. Leonards | New South Wales | 2065 | Australia | Details | |
| Local Institution - 0020 | Nedlands | Western Australia | 6009 | Australia | Details | |
| Local Institution - 0021 | Elizabeth Vale | South Australia | 5112 | Australia | Details | |
| Local Institution - 0022 | Clayton | Victoria | 3168 | Australia | Details | |
| Local Institution - 0023 | Gdansk | 80-952 | Poland | Details | ||
| Local Institution - 0025 | Warszawa | 02-781 | Poland | Details | ||
| Local Institution - 0026 | Krakow | 31-826 | Poland | Details | ||
| Local Institution - 0028 | Jacksonville | Florida | 32204 | United States | Details | |
| Local Institution - 0030 | Mexico | Distrito Federal | 14000 | Mexico | Details | |
| Local Institution - 0031 | Morelia | Michoacan | 58000 | Mexico | Details | |
| Local Institution - 0032 | Leon de los Aldama | Guanajuato | 37000 | Mexico | Details | |
| Local Institution - 0033 | Monterrey | Nuevo LEON | 64320 | Mexico | Details | |
| Local Institution - 0034 | Mexico City | Distrito Federal | 03100 | Mexico | Details | |
| Local Institution - 0035 | Oaxaca | 68000 | Mexico | Details | ||
| Local Institution - 0036 | Douglas | Queensland | 4814 | Australia | Details | |
| Local Institution - 0037 | Bydgoszcz | 85-796 | Poland | Details | ||
| Local Institution - 0039 | Paris | 75005 | France | Details | ||
| Local Institution - 0040 | Villejuif Cedex | 94805 | France | Details | ||
| Local Institution - 0042 | Milano | MI | 20133 | Italy | Details | |
| Local Institution - 0043 | Torino | TO | 10126 | Italy | Details | |
| Local Institution - 0044 | Cuneo | 12100 | Italy | Details | ||
| Local Institution - 0045 | London | Greater London | SW3 6JJ | United Kingdom | Details | |
| Local Institution - 0046 | Manchester | Greater Manchester | M20 4BX | United Kingdom | Details | |
| Local Institution - 0047 | Southampton | Hampshire | SO16 6YD | United Kingdom | Details | |
| Local Institution - 0049 | Newcastle Upon Tyne | Durham | NE4 6BE | United Kingdom | Details | |
| Local Institution - 0050 | Birmingham | West Midlands | B15 2TH | United Kingdom | Details | |
| Local Institution - 0051 | Thessaloniki | 54007 | Greece | Details | ||
| Local Institution - 0054 | Lyon | 69373 | France | Details | ||
| Local Institution - 0055 | Nice Cedex 2 | 06189 | France | Details | ||
| Local Institution - 0060 | Jerusalem | 91120 | Israel | Details | ||
| Local Institution - 0061 | Ramat-gan | 52621 | Israel | Details | ||
| Local Institution - 0062 | Haifa | 31096 | Israel | Details | ||
| Local Institution - 0063 | Petah-tikva | 49100 | Israel | Details | ||
| Local Institution - 0064 | Tel-Aviv | 64239 | Israel | Details | ||
| Local Institution - 0065 | Muenchen | 81675 | Germany | Details | ||
| Local Institution - 0066 | Wuerzburg | 97070 | Germany | Details | ||
| Local Institution - 0067 | Hamburg | 20246 | Germany | Details | ||
| Local Institution - 0068 | Bonn | 53127 | Germany | Details | ||
| Local Institution - 0069 | Ulm | 89081 | Germany | Details | ||
| Local Institution - 0070 | Mainz | 55131 | Germany | Details | ||
| Local Institution - 0071 | Wien | 1090 | Austria | Details | ||
| Local Institution - 0072 | Basel | 4031 | Switzerland | Details | ||
| Local Institution - 0073 | Zuerich | 8091 | Switzerland | Details | ||
| Local Institution - 0074 | Leipzig | 04103 | Germany | Details | ||
| Local Institution - 0075 | Linz | 4010 | Austria | Details | ||
| Local Institution - 0077 | Brisbane | Queensland | 4102 | Australia | Details | |
| Local Institution - 0078 | Freiburg | 79106 | Germany | Details | ||
| Local Institution - 0079 | Heidelberg | 69120 | Germany | Details | ||
| Local Institution - 0080 | Boston | Massachusetts | 02215 | United States | Details | |
| Local Institution - 0081 | Valencia | 46026 | Spain | Details | ||
| Local Institution - 0082 | Madrid | 28041 | Spain | Details | ||
| Local Institution - 0083 | Barcelona | 08035 | Spain | Details | ||
| Local Institution - 0084 | Sevilla | 41013 | Spain | Details | ||
| Local Institution - 0085 | Madrid | 28034 | Spain | Details | ||
| Local Institution - 0088 | Paris | 75020 | France | Details | ||
| Local Institution - 0089 | Strasbourg | 67200 | France | Details | ||
| Local Institution - 0090 | Lille | 59000 | France | Details | ||
| Local Institution - 0091 | Sutton | Surrey | SM2 5PT | United Kingdom | Details | |
| Local Institution - 0092 | Hannover | 30625 | Germany | Details | ||
| Local Institution - 0093 | Boston | Massachusetts | 02215 | United States | Details | |
| Local Institution - 0094 | Bordeaux | 33075 | France | Details | ||
| Local Institution - 0095 | Seoul | 06591 | Korea, Republic of | Details | ||
| Local Institution - 0096 | Gangnam-gu | 06351 | Korea, Republic of | Details | ||
| Local Institution - 0097 | Taichung | 40705 | Taiwan | Details | ||
| Local Institution - 0098 | Taipei | 10002 | Taiwan | Details | ||
| Local Institution - 0099 | Takatsuki-shi | Osaka | 5698686 | Japan | Details | |
| Local Institution - 0100 | Kashiwa | Chiba | 277-8577 | Japan | Details | |
| Local Institution - 0101 | Chuo-ku | Tokyo | 1040045 | Japan | Details | |
| Local Institution - 0102 | Kobe-shi | Hyogo | 650-0017 | Japan | Details | |
| Local Institution - 0104 | Koto-ku | Tokyo | 135-8550 | Japan | Details | |
| Local Institution - 0105 | Sapporo-shi | Hokkaido | 0608648 | Japan | Details | |
| Local Institution - 0106 | Nagoya | Aichi | 4648681 | Japan | Details | |
| Local Institution - 0107 | Akashi-shi | Hyogo | 6738558 | Japan | Details | |
| Local Institution - 0108 | Sendai-shi | Miyagi | 9808574 | Japan | Details | |
| Local Institution - 0109 | Kita-gun | 7610793 | Japan | Details | ||
| Local Institution - 0110 | Seoul | 05505 | Korea, Republic of | Details | ||
| Local Institution - 0111 | Atlanta | Georgia | 30322 | United States | Details | |
| Local Institution - 0113 | Fukuoka-shi | Fukuoka | 8108563 | Japan | Details | |
| Local Institution - 0114 | Sunto-gun | Shizuoka | 4118777 | Japan | Details | |
| Local Institution - 0117 | Barretos | Sao Paulo | 14784-400 | Brazil | Details | |
| Local Institution - 0118 | Sao Paulo | 01246-000 | Brazil | Details | ||
| Local Institution - 0120 | Porto Alegre | RIO Grande DO SUL | 90610000 | Brazil | Details | |
| Local Institution - 0121 | Ijui | RIO Grande DO SUL | 98700-000 | Brazil | Details | |
| Local Institution - 0122 | Porto Alegre | RIO Grande DO SUL | 90035-903 | Brazil | Details | |
| Local Institution - 0123 | Sao Jose De Rio Preto | Sao Paulo | 15091-000 | Brazil | Details | |
| Local Institution - 0124 | Sao Paulo | 04039-004 | Brazil | Details | ||
| Local Institution - 0125 | Morgantown | West Virginia | 26506-9162 | United States | Details | |
| Local Institution - 0126 | Marseille | 13005 | France | Details | ||
| Local Institution - 0127 | Darlinghurst | New South Wales | 2010 | Australia | Details | |
| Local Institution - 0128 | Gosford | New South Wales | 2250 | Australia | Details | |
| Local Institution - 0129 | Gliwice | 44-101 | Poland | Details | ||
| Local Institution - 0130 | L'Hospitalet Del Llobregat | 08908 | Spain | Details | ||
| Local Institution - 0131 | Melbourne | Victoria | 3000 | Australia | Details | |
| Local Institution - 0132 | Sheffield | S10 2SJ | United Kingdom | Details | ||
| Local Institution - 0133 | Amiens | Somme | 80054 | France | Details | |
| Local Institution - 0134 | Tucson | Arizona | 85724-5024 | United States | Details | |
| Local Institution - 0135 | Duarte | California | 91010 | United States | Details | |
| Local Institution - 0138 | Lyon | 69004 | France | Details | ||
| Local Institution - 0139 | Dallas | Texas | 75390 | United States | Details | |
| Local Institution - 0140 | La Tronche | 38700 | France | Details | ||
| Local Institution - 0142 | Blacktown | New South Wales | 2148 | Australia | Details | |
| Local Institution - 0146 | Osakasayaha | Osaka | 5898511 | Japan | Details | |
| Local Institution - 0147 | Dublin 8 | Dublin | Ireland | Details | ||
| Local Institution - 0148 | Belo Horizonte | Minas Gerais | 30130-090 | Brazil | Details | |
| Local Institution - 0149 | Kitaadachi-gun | Saitama | 3620806 | Japan | Details | |
| Local Institution - 0150 | Yokohama-shi | Kanagawa | 2360004 | Japan | Details | |
| Local Institution - 0151 | Natori-shi | Miyagi | 9811293 | Japan | Details | |
| Local Institution - 0152 | Isehara | Kanagawa | 2591193 | Japan | Details | |
| Local Institution - 0153 | Bunkyo-ku | Tokyo | 1138519 | Japan | Details |
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