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| NCT ID | NCT03797326 |
| Title | Efficacy and Safety of Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) in Previously Treated Participants With Select Solid Tumors (MK-7902-005/E7080-G000-224/LEAP-005) |
| Recruitment | Completed |
| Gender | both |
| Phase | Phase II |
| Variant Requirements | No |
| Sponsors | Merck Sharp & Dohme Corp. |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | ITA | ISR | GBR | FRA | ESP | DEU | CHE | CAN | AUS | ARG |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| City of Hope ( Site 0002) | Duarte | California | 91010 | United States | Details | |
| Cedars Sinai Medical Center ( Site 0003) | Los Angeles | California | 90048 | United States | Details | |
| University of California Davis Comprehensive Cancer Center ( Site 0005) | Sacramento | California | 95817 | United States | Details | |
| University of Colorado, Anschutz Cancer Pavilion ( Site 0007) | Aurora | Colorado | 80045 | United States | Details | |
| University of Florida-Health Cancer Center-Orlando ( Site 0015) | Orlando | Florida | 32806 | United States | Details | |
| Rutgers Cancer Institute of New Jersey ( Site 0009) | New Brunswick | New Jersey | 08901 | United States | Details | |
| Laura and Isaac Perlmutter Cancer Center at NYU Langone Health ( Site 0023) | New York | New York | 10016 | United States | Details | |
| Sanford Fargo Medical Center ( Site 0059) | Fargo | North Dakota | 58102 | United States | Details | |
| Lehigh Valley Hospital- Cedar Crest ( Site 0047) | Allentown | Pennsylvania | 18103 | United States | Details | |
| Sanford Cancer Center ( Site 0058) | Sioux Falls | South Dakota | 57104 | United States | Details | |
| West Cancer Center - East Campus ( Site 0018) | Germantown | Tennessee | 38138 | United States | Details | |
| Mary Crowley Cancer Research Centers - Medical City Hospital ( Site 0049) | Dallas | Texas | 75230 | United States | Details | |
| Swedish Medical Center ( Site 0021) | Seattle | Washington | 98104 | United States | Details | |
| University of Wisconsin Carbone Cancer Center ( Site 0017) | Madison | Wisconsin | 53792-0001 | United States | Details | |
| Fundacion Favaloro para la Docencia e Investigacion Medica ( Site 2106) | Ciudad Autonoma de Buenos Aires | Buenos Aires | C1078AAI | Argentina | Details | |
| Hospital Aleman ( Site 2100) | Buenos Aires | Caba | 1118 | Argentina | Details | |
| Hospital Britanico de Buenos Aires ( Site 2109) | Ciudad de Buenos Aires | Caba | C1280AEB | Argentina | Details | |
| Instituto de Oncologia de Rosario ( Site 2105) | Rosario | Santa Fe | S2000KZE | Argentina | Details | |
| CEMIC ( Site 2104) | Buenos Aires | C1431FWO | Argentina | Details | ||
| IDIM Instituto de Diagnostico e Investigaciones Metabolicas ( Site 2101) | Caba | C1012AAR | Argentina | Details | ||
| Royal Brisbane and Women s Hospital ( Site 0901) | Herston | Queensland | 4029 | Australia | Details | |
| Alfred Health ( Site 0902) | Melbourne | Victoria | 3004 | Australia | Details | |
| Sir Charles Gairdner Hospital ( Site 0903) | Nedlands | Western Australia | 6009 | Australia | Details | |
| BC Cancer - Abbotsford ( Site 0200) | Abbotsford | British Columbia | V2S 0C2 | Canada | Details | |
| CancerCare Manitoba ( Site 0201) | Winnipeg | Manitoba | R3E 0V9 | Canada | Details | |
| Hamilton Health Sciences-Juravinski Cancer Centre ( Site 0208) | Hamilton | Ontario | L8V 4X2 | Canada | Details | |
| Sunnybrook Research Institute ( Site 0207) | Toronto | Ontario | M4N 3M5 | Canada | Details | |
| Princess Margaret Cancer Centre ( Site 0202) | Toronto | Ontario | M5G 2M9 | Canada | Details | |
| Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0210) | Montreal | Quebec | H2X 3E4 | Canada | Details | |
| CHU de Quebec Universite de Laval ( Site 0206) | Quebec | G1R 2J6 | Canada | Details | ||
| Centro Investigación del Cáncer James Lind ( Site 1203) | Temuco | Araucania | 4780000 | Chile | Details | |
| Fundacion Arturo Lopez Perez ( Site 1201) | Santiago | Region M. De Santiago | 7500921 | Chile | Details | |
| Pontificia Universidad Catolica de Chile ( Site 1202) | Santiago | Region M. De Santiago | 8330024 | Chile | Details | |
| Hospital Clinico Universidad de Chile ( Site 1200) | Santiago | Region M. De Santiago | 8380456 | Chile | Details | |
| Fundacion Colombiana de Cancerologia Clinica Vida ( Site 1105) | Medellin | Antioquia | 050030 | Colombia | Details | |
| Instituto Nacional de Cancerologia E.S.E ( Site 1102) | Bogota | Distrito Capital De Bogota | 110321 | Colombia | Details | |
| Oncologos del Occidente S.A. ( Site 1106) | Pereira | Risaralda | 660001 | Colombia | Details | |
| Fundacion Valle del Lili ( Site 1101) | Cali | Valle Del Cauca | 760032 | Colombia | Details | |
| Centre Antoine Lacassagne ( Site 0404) | Nice | Alpes-Maritimes | 06189 | France | Details | |
| Centre Leon Berard ( Site 0405) | Lyon | Auvergne | 69373 | France | Details | |
| Institut Claudius Regaud IUCT Oncopole ( Site 0403) | Toulouse | Haute-Garonne | 31059 | France | Details | |
| Centre Oscar Lambret ( Site 0401) | Lille | Nord | 59000 | France | Details | |
| Institut de Cancerologie de l Ouest Centre Rene Gauducheau ( Site 0402) | Saint-Herblain | Val-de-Marne | 44805 | France | Details | |
| Institut Gustave Roussy ( Site 0400) | Villejuif | Val-de-Marne | 94800 | France | Details | |
| Robert Bosch GmbH ( Site 0307) | Stuttgart | Baden-Wurttemberg | 70376 | Germany | Details | |
| Universitaetsklinikum Regensburg ( Site 0304) | Regensburg | Bayern | 93053 | Germany | Details | |
| Universitaetsklinikum Frankfurt ( Site 0306) | Frankfurt am Main | Hessen | 60528 | Germany | Details | |
| HELIOS Dr. Horst Schmidt Kliniken Wiesbaden ( Site 0301) | Wiesbaden | Hessen | 65199 | Germany | Details | |
| SRH Wald-Klinikum Gera GmbH ( Site 0309) | Gera | Thuringen | 07548 | Germany | Details | |
| Universitaetsklinikum Jena ( Site 0302) | Jena | Thuringen | 07740 | Germany | Details | |
| Soroka Medical Center ( Site 0601) | Beer Sheva | 8457108 | Israel | Details | ||
| Rambam Medical Center ( Site 0602) | Haifa | 3109601 | Israel | Details | ||
| Hadassah Ein Kerem Medical Center ( Site 0604) | Jerusalem | 9112001 | Israel | Details | ||
| Chaim Sheba Medical Center ( Site 0600) | Ramat Gan | 5262000 | Israel | Details | ||
| Sourasky Medical Center ( Site 0603) | Tel Aviv | 6423906 | Israel | Details | ||
| Istituto Clinico Humanitas Research Hospital ( Site 1402) | Rozzano | Milano | Italy | Details | ||
| Policlinico Le Scotte - A.O. Senese ( Site 1401) | Siena | Toscana | 53100 | Italy | Details | |
| Istituto Nazionale Tumori Fondazione Pascale ( Site 1400) | Napoli | 80131 | Italy | Details | ||
| Fondazione Policlinico Universitario A. Gemelli ( Site 1403) | Roma | 00168 | Italy | Details | ||
| Asan Medical Center ( Site 1002) | Songpagu | Seoul | 05505 | Korea, Republic of | Details | |
| Seoul National University Hospital ( Site 1000) | Seoul | 03080 | Korea, Republic of | Details | ||
| Severance Hospital Yonsei University Health System ( Site 1001) | Seoul | 03722 | Korea, Republic of | Details | ||
| Arkhangelsk Clinical Oncological Dispensary ( Site 1600) | Arkhangelsk | Arkhangel Skaya Oblast | 163045 | Russian Federation | Details | |
| Russian Oncological Research Center n.a. N.N. Blokhin ( Site 1604) | Moscow | Moskva | 115478 | Russian Federation | Details | |
| Leningrad Regional Oncology Center ( Site 1609) | Saint-Petersburg | Sankt-Peterburg | 188663 | Russian Federation | Details | |
| Scientific Research Oncology Institute n.a. N.N.Petrov ( Site 1610) | Saint-Petersburg | Sankt-Peterburg | 197758 | Russian Federation | Details | |
| City Clinical Oncology Center ( Site 1608) | Saint-Petersburg | Sankt-Peterburg | 198255 | Russian Federation | Details | |
| Republican Clinical Oncology Dispensary of Tatarstan MoH ( Site 1603) | Kazan | Tatarstan, Respublika | 420029 | Russian Federation | Details | |
| Hospital Clinic i Provincial ( Site 0703) | Barcelona | 08036 | Spain | Details | ||
| Hospital Universitario Gregorio Maranon ( Site 0701) | Madrid | 28009 | Spain | Details | ||
| Clinica Universitaria de Navarra ( Site 0704) | Madrid | 28027 | Spain | Details | ||
| Hospital Ramon y Cajal ( Site 0702) | Madrid | 28034 | Spain | Details | ||
| Inselspital Universitaetsspital Bern ( Site 1705) | Bern | Berne | 3010 | Switzerland | Details | |
| Kantonsspital Graubuenden ( Site 1704) | Chur | Grisons | 7000 | Switzerland | Details | |
| Kantonsspital St. Gallen ( Site 1702) | St. Gallen | Sankt Gallen | 9007 | Switzerland | Details | |
| Ospedale Regionale di Bellinzona e Valli ( Site 1703) | Bellinzona | Ticino | 6500 | Switzerland | Details | |
| Hopitaux Universitaires de Geneve HUG ( Site 1701) | Geneve | 1211 | Switzerland | Details | ||
| Universitaetsspital Zurich ( Site 1700) | Zurich | 8091 | Switzerland | Details | ||
| National Cheng Kung University Hospital ( Site 3003) | Tainan | 704 | Taiwan | Details | ||
| National Taiwan University Hospital ( Site 3000) | Taipei | 10002 | Taiwan | Details | ||
| Chulalongkorn University ( Site 5001) | Bangkok | Krung Thep Maha Nakhon | 10330 | Thailand | Details | |
| Ramathibodi Hospital. ( Site 5002) | Bangkok | Krung Thep Maha Nakhon | 10400 | Thailand | Details | |
| Siriraj Hospital ( Site 5003) | Bangkok | Krung Thep Maha Nakhon | 10700 | Thailand | Details | |
| Cambridge University Hospitals NHS Trust ( Site 0803) | Cambridge | Cambridgeshire | CB2 0QQ | United Kingdom | Details | |
| Leicester Royal Infirmary. Univ. Hosp. of Leicester NHS Trust ( Site 0804) | Leicester | Leicestershire | LE1 5WW | United Kingdom | Details | |
| Guy's Hospital ( Site 0806) | London | London, City Of | SE1 9RT | United Kingdom | Details | |
| Royal Marsden Hospital (Sutton) ( Site 0800) | London | Surrey | SM3 5PT | United Kingdom | Details | |
| Christie NHS Foundation Trust ( Site 0805) | Manchester | M20 4BX | United Kingdom | Details |