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| NCT ID | NCT04199104 |
| Title | A Study of Pembrolizumab (MK-3475) With or Without Lenvatinib (E7080/MK-7902) as First Line (1L) Intervention in a Programmed Cell Death-ligand 1 (PD-L1) Selected Population With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC) (LEAP-010) (MK-7902-010) (LEAP-10) |
| Acronym | LEAP-10 |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Merck Sharp & Dohme Corp. |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | TUR | POL | ITA | HUN | GBR | FRA | ESP | DEU | CAN | BRA | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| California Cancer Associates for Research & Excellence ( Site 0025) | Fresno | California | 93720 | United States | Details | |
| California Cancer Associates for Research & Excellence ( Site 0059) | San Marcos | California | 92069 | United States | Details | |
| University of Colorado Cancer Center ( Site 0023) | Aurora | Colorado | 80045 | United States | Details | |
| University of Connecticut Health Center ( Site 0020) | Farmington | Connecticut | 06030 | United States | Details | |
| Memorial Regional Hospital-Memorial Cancer Institute ( Site 0069) | Hollywood | Florida | 33021 | United States | Details | |
| Georgia Cancer Center at Augusta University ( Site 0013) | Augusta | Georgia | 30912 | United States | Details | |
| Northwest Georgia Oncology Centers PC ( Site 0028) | Marietta | Georgia | 30060 | United States | Details | |
| University of Kansas Cancer Center ( Site 0033) | Westwood | Kansas | 66205 | United States | Details | |
| University of Louisville, James Graham Brown Cancer Center ( Site 0045) | Louisville | Kentucky | 40202 | United States | Details | |
| Dana Farber Cancer Institute ( Site 0019) | Boston | Massachusetts | 02215 | United States | Details | |
| University of Michigan ( Site 0064) | Ann Arbor | Michigan | 48109-5936 | United States | Details | |
| Karmanos Cancer Institute ( Site 0054) | Detroit | Michigan | 48201 | United States | Details | |
| Henry Ford Health System ( Site 0001) | Detroit | Michigan | 48202 | United States | Details | |
| Washington University School of Medicine ( Site 0060) | Saint Louis | Missouri | 63110 | United States | Details | |
| St. Vincent Frontier Cancer Center ( Site 0008) | Billings | Montana | 59102 | United States | Details | |
| Oncology Hematology West, PC dba Nebraska Cancer Specialists ( Site 0053) | Omaha | Nebraska | 68130 | United States | Details | |
| John Theurer Cancer Center at Hackensack University Medical Center ( Site 0002) | Hackensack | New Jersey | 07601 | United States | Details | |
| Weill Cornell Medicine New York Presbyterian Hospital ( Site 0040) | New York | New York | 10021 | United States | Details | |
| SUNY Upstate Medical University ( Site 0051) | Syracuse | New York | 13210 | United States | Details | |
| University of North Carolina- Chapel Hill ( Site 0056) | Chapel Hill | North Carolina | 27514 | United States | Details | |
| Duke Cancer Center ( Site 0044) | Durham | North Carolina | 27710 | United States | Details | |
| Providence Portland Medical Center ( Site 0048) | Portland | Oregon | 97213 | United States | Details | |
| Blue Ridge Cancer Care ( Site 0015) | Blacksburg | Virginia | 24060 | United States | Details | |
| Inova Schar Cancer Institute ( Site 0009) | Fairfax | Virginia | 22031 | United States | Details | |
| Cancer Care Northwest ( Site 0017) | Spokane Valley | Washington | 99216 | United States | Details | |
| University of Wisconsin- Madison Carbone Cancer Center ( Site 0006) | Madison | Wisconsin | 53792 | United States | Details | |
| Chris OBrien Lifehouse ( Site 1002) | Camperdown | New South Wales | 2050 | Australia | Details | |
| St George Hospital ( Site 1001) | Kogarah | New South Wales | 2217 | Australia | Details | |
| Royal Adelaide Hospital ( Site 1004) | Adelaide | South Australia | 5000 | Australia | Details | |
| Oncocentro Ceara ( Site 0412) | Fortaleza | Ceara | 60135-237 | Brazil | Details | |
| Fundacao Sao Francisco Xavier ( Site 0409) | Ipatinga | Minas Gerais | 35162-189 | Brazil | Details | |
| ELO Pesquisa Clinica ( Site 0405) | Maringa | Parana | 87015-200 | Brazil | Details | |
| Hospital de Passo Fundo ( Site 0401) | Passo Fundo | Rio Grande Do Sul | 99010-260 | Brazil | Details | |
| Clinica LACKS ( Site 0402) | Pelotas | Rio Grande Do Sul | 96020-080 | Brazil | Details | |
| Hospital Nossa Senhora da Conceição-Centro Integrado de Pesquisa em Oncologia ( Site 0414) | Porto Alegre | Rio Grande Do Sul | 91350-200 | Brazil | Details | |
| A.C. Camargo Cancer Center ( Site 0407) | Sao Paulo | 01509-900 | Brazil | Details | ||
| Princess Margaret Cancer Centre ( Site 0200) | Toronto | Ontario | M5G 1Z5 | Canada | Details | |
| McGill University Health Centre ( Site 0206) | Montreal | Quebec | H4A 3J1 | Canada | Details | |
| Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 0 | Quebec City | Quebec | G1J 1Z4 | Canada | Details | |
| Beijing Cancer Hospital ( Site 3314) | Beining | Beijing | 100036 | China | Details | |
| Peking Union Medical College Hospital ( Site 3304) | Bejiing | Beijing | 100032 | China | Details | |
| Chongqing Cancer Hospital ( Site 3327) | Chongqing | Chongqing | 400030 | China | Details | |
| Fujian Provincial Cancer Hospital ( Site 3326) | Fuzhou | Fujian | 350014 | China | Details | |
| Guangxi Medical University Affiliated Tumor Hospital ( Site 3322) | Nanning | Guangxi | 530000 | China | Details | |
| Guizhou Cancer Hospital ( Site 3330) | Guiyang | Guizhou | 550003 | China | Details | |
| The Third Affiliated Hospital of Harbin Medical University ( Site 3302) | Harbin | Heilongjiang | 150081 | China | Details | |
| Henan Cancer Hospital ( Site 3309) | Zhengzhou | Henan | 450008 | China | Details | |
| Wuhan Union hospital Cancer Center ( Site 3307) | Wuhan | Hubei | 430000 | China | Details | |
| Tongji Hospital Tongji Medical,Science & Technology ( Site 3316) | Wuhan | Hubei | 430030 | China | Details | |
| Hunan Cancer Hospital ( Site 3311) | Changsha | Hunan | 410000 | China | Details | |
| Xiangya Hospital of Central South University ( Site 3305) | Changsha | Hunan | 410008 | China | Details | |
| Jiangxi Cancer Hospital ( Site 3313) | Nanchang | Jiangxi | 330029 | China | Details | |
| Jilin Cancer Hospital ( Site 3310) | Changchun | Jilin | 130000 | China | Details | |
| The First Affiliated Hospital of Xi an Jiaotong University ( Site 3328) | XI An | Shaanxi | 710000 | China | Details | |
| Fudan University Shanghai Cancer Center ( Site 3324) | Shanghai | Shanghai | 200032 | China | Details | |
| Shanghai East Hospital ( Site 3300) | Shanghai | Shanghai | 200120 | China | Details | |
| West China Hospital of Sichuan University ( Site 3308) | Chengdu | Sichuan | 610047 | China | Details | |
| Tianjin Medical University Cancer Hospital ( Site 3312) | Tianjin | Tianjin | 300060 | China | Details | |
| Zhejiang Cancer Hospital ( Site 3303) | Hangzhou | Zhejiang | 310022 | China | Details | |
| Centre Leon Berard ( Site 1901) | Lyon | Auvergne | 69008 | France | Details | |
| Hopital de la Timone ( Site 1903) | Marseille | Bouches-du-Rhone | 13005 | France | Details | |
| Hopital Foch ( Site 1905) | Suresnes | Hauts-de-Seine | 92151 | France | Details | |
| Centre Henri Becquerel ( Site 1904) | Rouen | Seine-Maritime | 76038 | France | Details | |
| Gustave Roussy ( Site 1906) | Villejuif | Val-de-Marne | 94800 | France | Details | |
| Universitaetsklinikum Tuebingen ( Site 2108) | Tuebingen | Baden-Wurttemberg | 72076 | Germany | Details | |
| Universitaetsklinikum Ulm ( Site 2102) | Ulm | Baden-Wurttemberg | 89075 | Germany | Details | |
| Universitaetsklinikum Regensburg ( Site 2100) | Regensburg | Bayern | 93053 | Germany | Details | |
| Universitaetsklinikum Frankfurt ( Site 2107) | Frankfurt | Hessen | 60590 | Germany | Details | |
| KRH Klinikum Siloah ( Site 2103) | Hannover | Niedersachsen | 30459 | Germany | Details | |
| Universitaetsklinikum Koeln ( Site 2111) | Koeln | Nordrhein-Westfalen | 50937 | Germany | Details | |
| Universitätsklinikum Leipzig-Department for ENT ( Site 2106) | Leipzig | Sachsen | 04103 | Germany | Details | |
| Charite Universitätsmedizin Berlin Campus Benjamin Franklin ( Site 2112) | Berlin | 12203 | Germany | Details | ||
| Borsod-Abaúj-Zemplén Megyei Központi Kórház és Egyetemi Okta-Klinikai Onkológiai és Sugárterápiás Ce | Miskolc | Borsod-Abauj-Zemplen | 3526 | Hungary | Details | |
| Szegedi Egyetem Szent-Gyorgyi Albert Klinikai Kozpont ( Site 2207) | Szeged | Csongrad | 6720 | Hungary | Details | |
| Jasz Nagykun Szolnok Megyei Hetenyi Geza Korhaz Rendelointezet ( Site 2200) | Szolnok | Jasz-Nagykun-Szolnok | 5004 | Hungary | Details | |
| Uzsoki Utcai Korhaz ( Site 2201) | Budapest | Vas | 1145 | Hungary | Details | |
| Orszagos Onkologiai Intezet ( Site 2202) | Budapest | 1122 | Hungary | Details | ||
| Debreceni Egyetem Klinikai Kozpont ( Site 2206) | Debrecen | 4032 | Hungary | Details | ||
| Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia ( Site 2402) | Brescia | 25123 | Italy | Details | ||
| Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 2400) | Milano | 20133 | Italy | Details | ||
| IEO Istituto Europeo di Oncologia ( Site 2406) | Milano | 20141 | Italy | Details | ||
| ASST Santi Paolo e Carlo - Presidio Ospedaliero San Paolo ( Site 2405) | Milano | 20142 | Italy | Details | ||
| Istituto Oncologico Veneto ( Site 2404) | Padova | 35128 | Italy | Details | ||
| ASL Liguria 2 - Ospedale San Paolo ( Site 2401) | Savona | 17100 | Italy | Details | ||
| Aichi Cancer Center Hospital ( Site 1113) | Nagoya | Aichi | 4648681 | Japan | Details | |
| Nagoya University Hospital ( Site 1106) | Nagoya | Aichi | 466-8560 | Japan | Details | |
| Chiba cancer center ( Site 1110) | Chiba-shi | Chiba | 260-8717 | Japan | Details | |
| National Cancer Center Hospital East ( Site 1100) | Kashiwa | Chiba | 2778577 | Japan | Details | |
| Hyogo Cancer Center ( Site 1112) | Akashi | Hyogo | 673-8558 | Japan | Details | |
| Kagawa University Hospital ( Site 1108) | Kita-gun | Kagawa | 761-0793 | Japan | Details | |
| Yokohama City University Hospital ( Site 1104) | Yokohama | Kanagawa | 2360064 | Japan | Details | |
| Kindai University Hospital ( Site 1107) | Osakasayama | Osaka | 5898511 | Japan | Details | |
| Shizuoka Cancer Center Hospital and Research Institute ( Site 1105) | Sunto-gun | Shizuoka | 411-8777 | Japan | Details | |
| National Hospital Organization Kyushu Medical Center ( Site 1111) | Fukuoka | 810-8563 | Japan | Details | ||
| Hiroshima University Hospital ( Site 1109) | Hiroshima | 7348551 | Japan | Details | ||
| National Cancer Center Hospital ( Site 1102) | Tokyo | 104-0045 | Japan | Details | ||
| The Cancer Institute Hospital of JFCR ( Site 1103) | Tokyo | 135-8550 | Japan | Details | ||
| Tokyo Medical and Dental University Hospital ( Site 1101) | Tokyo | Japan | Details | |||
| Chonnam National University Hwasun Hospital ( Site 1202) | Hwasun-gun | Jeonranamdo | 58128 | Korea, Republic of | Details | |
| Seoul National University Bundang Hospital ( Site 1205) | Seongnam-si | Kyonggi-do | 13620 | Korea, Republic of | Details | |
| Ajou University Hospital ( Site 1200) | Suwon-si | Kyonggi-do | 16499 | Korea, Republic of | Details | |
| Asan Medical Center ( Site 1201) | Songpa-gu | Seoul | 05505 | Korea, Republic of | Details | |
| Keimyung University Dongsan Hospital ( Site 1203) | Daegu | Taegu-Kwangyokshi | 42601 | Korea, Republic of | Details | |
| The Catholic University of Korea Eunpyeong St Mary s Hospital ( Site 1204) | Seoul | 03312 | Korea, Republic of | Details | ||
| Cryptex Investigación Clínica S.A. de C.V. ( Site 0608) | Cuauhtémoc, Mexico City | Distrito Federal | 06100 | Mexico | Details | |
| Hospital Universitario "Dr. Jose Eleuterio Gonzalez" ( Site 0602) | Monterrey | Nuevo Leon | 64460 | Mexico | Details | |
| Christus Muguerza Clinica Vidriera ( Site 0607) | Monterrey | Nuevo Leon | 64570 | Mexico | Details | |
| Centro de Investigacion y Avances Medicos Especializados -CIAME ( Site 0604) | Cancun | Quintana Roo | 77500 | Mexico | Details | |
| Oaxaca Site Management Organization S.C. ( Site 0603) | Oaxaca | 68000 | Mexico | Details | ||
| Instituto Nacional de Enfermedades Neoplasicas ( Site 0701) | Lima | Muni Metro De Lima | Lima 34 | Peru | Details | |
| Hospital Nacional Guillermo Almenara Irigoyen ( Site 0700) | Lima | 15033 | Peru | Details | ||
| Hospital Nacional Edgardo Rebagliati Martins ( Site 0702) | Lima | 15072 | Peru | Details | ||
| Hospital Nacional Arzobispo Loayza ( Site 0703) | Lima | 15082 | Peru | Details | ||
| Hospital Nacional Cayetano Heredia ( Site 0704) | Lima | 15102 | Peru | Details | ||
| Dolnoslaskie Centrum Onkologii. ( Site 2507) | Wroclaw | Dolnoslaskie | 53-413 | Poland | Details | |
| Centrum Onkologii im prof Franciszka Lukaszczyka ( Site 2508) | Bydgoszcz | Kujawsko-pomorskie | 85-796 | Poland | Details | |
| Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie ( Site 2502) | Krakow | Malopolskie | 31-826 | Poland | Details | |
| Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworow Glowy i Szyi ( Site | Warszawa | Mazowieckie | 02-781 | Poland | Details | |
| Szpital Morski im. PCK. Szpitale Pomorskie Sp. Z o.o ( Site 2504) | Gdynia | Pomorskie | 81-519 | Poland | Details | |
| Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 2506) | Gliwice | Slaskie | 44-101 | Poland | Details | |
| Przychodnia Lekarska Komed ( Site 2500) | Konin | Wielkopolskie | 62-500 | Poland | Details | |
| Szpital Kliniczny im. Heliodora Swiecickiego Uniwers Medyczn ( Site 2509) | Poznan | Wielkopolskie | 60-780 | Poland | Details | |
| Altay Regional Oncology Dispensary ( Site 2611) | Barnaul | Altayskiy Kray | 656045 | Russian Federation | Details | |
| FSCC FMBA of Russia ( Site 2603) | Moscow | Moskva | 115682 | Russian Federation | Details | |
| Republican Clinical Oncology Dispensary of Tatarstan MoH ( Site 2609) | Kazan | Tatarstan, Respublika | 420029 | Russian Federation | Details | |
| Yaroslavl Regional SBIH Clinical Oncology Hospital ( Site 2605) | Yaroslavl | Yaroslavskaya Oblast | 150054 | Russian Federation | Details | |
| Hospital Duran i Reynals ( Site 2701) | Hospitalet de Llobregat | Barcelona | 08908 | Spain | Details | |
| H.U. Vall de Hebron ( Site 2700) | Barcelona | 08035 | Spain | Details | ||
| Hospital Universitario 12 de Octubre ( Site 2702) | Madrid | 28041 | Spain | Details | ||
| Hospital Universitario La Paz ( Site 2706) | Madrid | 28046 | Spain | Details | ||
| Hospital de Valme ( Site 2705) | Sevilla | 41014 | Spain | Details | ||
| Hospital Clinico Universitario Lozano Blesa ( Site 2703) | Zaragoza | 50009 | Spain | Details | ||
| National Cheng Kung University Hospital ( Site 1603) | Taiwan | Tainan | 704 | Taiwan | Details | |
| Chang Gung Medical Foundation. Kaohsiung Branch ( Site 1604) | Kaohsiung | 833 | Taiwan | Details | ||
| National Taiwan University Hospital ( Site 1600) | Taipei | 10048 | Taiwan | Details | ||
| MacKay Memorial Hospital ( Site 1602) | Taipei | 10449 | Taiwan | Details | ||
| Taipei Veterans General Hospital ( Site 1601) | Taipei | 11217 | Taiwan | Details | ||
| Hacettepe Universitesi Tip Fakultesi ( Site 2805) | Ankara | 06230 | Turkey | Details | ||
| Ankara Sehir Hastanesi ( Site 2802) | Ankara | 06800 | Turkey | Details | ||
| Trakya Universitesi Tip Fakultesi ( Site 2801) | Edirne | 22030 | Turkey | Details | ||
| Medipol Universite Hastanesi ( Site 2800) | Istanbul | 34214 | Turkey | Details | ||
| Ege Universitesi Tip Fakultesi Hastanesi ( Site 2804) | Izmir | 35040 | Turkey | Details | ||
| Medical Park Izmir Hospital ( Site 2807) | Izmir | 35575 | Turkey | Details | ||
| Inonu Universitesi Turgut Ozal Tip Merkezi ( Site 2803) | Malatya | 44280 | Turkey | Details | ||
| Aberdeen Royal Infirmary ( Site 2905) | Aberdeen | Aberdeen City | AB25 2ZN | United Kingdom | Details | |
| Guy's Hospital in London ( Site 2908) | London | London, City Of | SE1 9RT | United Kingdom | Details | |
| Royal Marsden NHS Foundation Trust ( Site 2910) | London | London, City Of | SW3 6JJ | United Kingdom | Details | |
| Mount Vernon Cancer Centre ( Site 2902) | Northwood | London, City Of | HA6 2RN | United Kingdom | Details | |
| Royal Marsden Hospital ( Site 2904) | Sutton | London, City Of | SM2 5PT | United Kingdom | Details | |
| Nottingham City Hospital ( Site 2907) | Nottingham | Nottinghamshire | NG5 1PB | United Kingdom | Details | |
| Taunton and Somerset Hospital ( Site 2900) | Taunton | Somerset | TA1 5DA | United Kingdom | Details | |
| Christie NHS Foundation Trust ( Site 2903) | Manchester | M20 4BX | United Kingdom | Details |