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NCT ID | NCT04428151 |
Title | Lenvatinib (E7080/MK-7902) in Combination With Pembrolizumab (MK-3475) vs. Standard Chemotherapy and Lenvatinib Monotherapy in Participants With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma That Progressed After Platinum Therapy and Immunotherapy (MK-7902-009/E7080-G000-228/LEAP-009) |
Recruitment | Active, not recruiting |
Gender | both |
Phase | Phase II |
Variant Requirements | No |
Sponsors | Merck Sharp & Dohme Corp. |
Indications | |
Therapies | |
Age Groups: | adult | senior |
Covered Countries | USA | ROU | NOR | ISR | GBR | FRA | ESP | DNK | CAN | BRA | AUS |
Facility | Status | City | State | Zip | Country | Details |
---|---|---|---|---|---|---|
City of Hope ( Site 1519) | Duarte | California | 91010 | United States | Details | |
UCLA Hematology/Oncology - Westwood (Building 100) ( Site 1568) | Los Angeles | California | 90095 | United States | Details | |
Yale-New Haven Hospital-Yale Cancer Center ( Site 1505) | New Haven | Connecticut | 06510 | United States | Details | |
Georgetown University Medical Center ( Site 1520) | Washington | District of Columbia | 20007 | United States | Details | |
UF Health ( Site 1554) | Gainesville | Florida | 32608 | United States | Details | |
Mid Florida Hematology and Oncology Center ( Site 1606) | Orange City | Florida | 32763 | United States | Details | |
Cleveland Clinic Florida ( Site 1596) | Weston | Florida | 33331 | United States | Details | |
Georgia Cancer Center at Augusta University ( Site 1575) | Augusta | Georgia | 30912 | United States | Details | |
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital-Research ( Site 1521) | Marietta | Georgia | 30060 | United States | Details | |
Memorial Health University Medical Center ( Site 1626) | Savannah | Georgia | 31404 | United States | Details | |
Beacon Cancer Care ( Site 1599) | Post Falls | Idaho | 83854 | United States | Details | |
Rush University Medical Center ( Site 1560) | Chicago | Illinois | 60607 | United States | Details | |
NorthShore University HealthSystem - Evanston Hospital ( Site 1614) | Evanston | Illinois | 60201 | United States | Details | |
IU Health Ball Memorial Hospital, Inc.-IU Health Ball Memorial Cancer Center ( Site 1612) | Muncie | Indiana | 47303 | United States | Details | |
University of Iowa ( Site 1572) | Iowa City | Iowa | 52242 | United States | Details | |
University of Kansas Cancer Center ( Site 1538) | Westwood | Kansas | 66205 | United States | Details | |
Norton Hospital-Norton Cancer Institute - Downtown ( Site 1601) | Louisville | Kentucky | 40205 | United States | Details | |
Mercy Health-Paducah Cancer Center ( Site 1623) | Paducah | Kentucky | 42003 | United States | Details | |
Our Lady of the Lake RMC-Clinical Research ( Site 1624) | Baton Rouge | Louisiana | 70808 | United States | Details | |
Mary Bird Perkins Cancer Center Baton Rouge ( Site 1622) | Baton Rouge | Louisiana | 70809 | United States | Details | |
University of Maryland Greenebaum Cancer Center ( Site 1522) | Baltimore | Maryland | 21201 | United States | Details | |
Boston Medical Center ( Site 1605) | Boston | Massachusetts | 02118 | United States | Details | |
University of Massachusetts Chan Medical School ( Site 1616) | Worcester | Massachusetts | 01655 | United States | Details | |
VA Ann Arbor Healthcare System ( Site 1584) | Ann Arbor | Michigan | 48105 | United States | Details | |
Barbara Ann Karmanos Cancer Institute ( Site 1566) | Detroit | Michigan | 48201 | United States | Details | |
Henry Ford Health System ( Site 1544) | Detroit | Michigan | 48202 | United States | Details | |
Hattiesburg Clinic ( Site 1515) | Hattiesburg | Mississippi | 39401 | United States | Details | |
Jackson Oncology Associates, PLLC-Clinical Trials ( Site 1625) | Jackson | Mississippi | 39202 | United States | Details | |
Washington University School of Medicine ( Site 1500) | Saint Louis | Missouri | 63110 | United States | Details | |
St. Vincent Frontier Cancer Center ( Site 1507) | Billings | Montana | 59102 | United States | Details | |
University Of Nebraska Medical Center ( Site 1570) | Omaha | Nebraska | 68105 | United States | Details | |
Oncology Hematology West P.C. dba Nebraska Cancer Specialists ( Site 1627) | Omaha | Nebraska | 68130 | United States | Details | |
John Theurer Cancer Center at Hackensack University Medical Center ( Site 1555) | Hackensack | New Jersey | 07601 | United States | Details | |
Rutgers Cancer Institute of New Jersey ( Site 1523) | New Brunswick | New Jersey | 08903 | United States | Details | |
Perlmutter Cancer Center at Winthrop Oncology Hematology Associates NYU Langone Health ( Site 1597) | Mineola | New York | 11501 | United States | Details | |
Laura and Isaac Perlmutter Cancer Center ( Site 1582) | New York | New York | 10016 | United States | Details | |
Levine Cancer Institute ( Site 1590) | Charlotte | North Carolina | 28204 | United States | Details | |
Duke Cancer Institute ( Site 1541) | Durham | North Carolina | 27710 | United States | Details | |
University of Cincinnati Medical Center ( Site 1567) | Cincinnati | Ohio | 45219 | United States | Details | |
University Hospital Cleveland ( Site 1578) | Cleveland | Ohio | 44106 | United States | Details | |
Cleveland Clinic Main ( Site 1598) | Cleveland | Ohio | 44195 | United States | Details | |
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive C | Columbus | Ohio | 43210 | United States | Details | |
Oklahoma Cancer Specialists and Research Institute, LLC ( Site 1508) | Tulsa | Oklahoma | 74146 | United States | Details | |
Gettysburg Cancer Center ( Site 1594) | Gettysburg | Pennsylvania | 17325 | United States | Details | |
Penn State Hershey Medical Center ( Site 1561) | Hershey | Pennsylvania | 17033 | United States | Details | |
Fox Chase Cancer Center ( Site 1502) | Philadelphia | Pennsylvania | 19111 | United States | Details | |
Medical University of South Carolina ( Site 1579) | Charleston | South Carolina | 29425 | United States | Details | |
St Francis Cancer Center-Research Office ( Site 1607) | Greenville | South Carolina | 29607 | United States | Details | |
The Center For Cancer And Blood Disorders ( Site 1569) | Fort Worth | Texas | 76104 | United States | Details | |
Utah Cancer Specialists ( Site 1621) | Salt Lake City | Utah | 84106 | United States | Details | |
Huntsman Cancer Institute ( Site 1532) | Salt Lake City | Utah | 84112 | United States | Details | |
Inova Schar Cancer Institute ( Site 1550) | Fairfax | Virginia | 22031-4867 | United States | Details | |
Hematology Oncology Associates of Fredericksburg ( Site 1537) | Fredericksburg | Virginia | 22408 | United States | Details | |
MultiCare Health System-MultiCare Oncology - Puget Sound ( Site 1609) | Tacoma | Washington | 98405 | United States | Details | |
Medical College of Wisconsin Clinical Cancer Center ( Site 1574) | Milwaukee | Wisconsin | 53226 | United States | Details | |
Mid North Coast Cancer Institute ( Site 0109) | Port Macquarie | New South Wales | 2444 | Australia | Details | |
Blacktown Hospital ( Site 0101) | Sydney | New South Wales | 2148 | Australia | Details | |
The Townsville Hospital ( Site 0107) | Douglas | Queensland | 4814 | Australia | Details | |
Gallipoli Medical Research Ltd-GMRF CTU ( Site 0105) | Greenslopes | Queensland | 4120 | Australia | Details | |
Royal Adelaide Hospital ( Site 0110) | Adelaide | South Australia | 5000 | Australia | Details | |
Monash Health ( Site 0102) | Clayton | Victoria | 3168 | Australia | Details | |
Hospital Nossa Senhora da Conceição-Centro Integrado de Pesquisa em Oncologia ( Site 0806) | Porto Alegre | Rio Grande Do Sul | 91350-200 | Brazil | Details | |
A. C. Camargo Cancer Center ( Site 0809) | Sao Paulo | 01509-010 | Brazil | Details | ||
Tom Baker Cancer Centre ( Site 0304) | Calgary | Alberta | T2N 4N2 | Canada | Details | |
BC Cancer-Vancouver Center ( Site 0306) | Vancouver | British Columbia | V5Z 4E6 | Canada | Details | |
Hamilton Health Sciences-Juravinski Cancer Centre ( Site 0307) | Hamilton | Ontario | L8V 5C2 | Canada | Details | |
Sunnybrook Research Institute ( Site 0308) | Toronto | Ontario | M4N 3M5 | Canada | Details | |
Instituto de Cancerología ( Site 0408) | Medellin | Antioquia | 050025 | Colombia | Details | |
Sociedad De Oncologia Y Hematologia Del Cesar ( Site 0404) | Valledupar | Cesar | 200001 | Colombia | Details | |
Oncomédica S.A.S ( Site 0409) | Montería | Cordoba | 230002 | Colombia | Details | |
Administradora Country S.A.S - Clínica del Country ( Site 0407) | Bogotá | Cundinamarca | 110221 | Colombia | Details | |
Rigshospitalet University Hospital Copenhagen ( Site 1000) | Copenhagen | Hovedstaden | 2100 | Denmark | Details | |
Hopital La Timone ( Site 0503) | Marseille | Bouches-du-Rhone | 13385 | France | Details | |
Centre de Cancerologie du Grand Montpellier ( Site 0508) | Montpellier | Herault | 34070 | France | Details | |
Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne-ONCOLOGY ( Site 0510) | Clermont-Ferrand | Puy-de-Dome | 63011 | France | Details | |
Centre de Lutte Contre le Cancer - Centre Henri Becquerel Normandie Rouen ( Site 0509) | Rouen | Seine-Maritime | 76038 | France | Details | |
Institut Gustave Roussy ( Site 0505) | Villejuif | Val-de-Marne | 94800 | France | Details | |
Institut Curie ( Site 0500) | Paris | 75005 | France | Details | ||
Soroka Medical Center-Oncology ( Site 0604) | Be'er Sheva | 8400000 | Israel | Details | ||
Rambam Health Care Campus-Oncology Division ( Site 0602) | Haifa | 3109601 | Israel | Details | ||
Hadassah Medical Center. Ein Kerem ( Site 0601) | Jerusalem | 9112001 | Israel | Details | ||
Chaim Sheba Medical Center ( Site 0600) | Ramat Gan | 5265601 | Israel | Details | ||
Seoul National University Bundang Hospital ( Site 1801) | Seongnam | Kyonggi-do | 13620 | Korea, Republic of | Details | |
Ajou University Hospital ( Site 1802) | Suwon | Kyonggi-do | 16499 | Korea, Republic of | Details | |
Severance Hospital Yonsei University Health System ( Site 1800) | Seoul | 03722 | Korea, Republic of | Details | ||
Samsung Medical Center ( Site 1803) | Seoul | 06351 | Korea, Republic of | Details | ||
Oslo universitetssykehus, Radiumhospitalet ( Site 1102) | Oslo | 0379 | Norway | Details | ||
Unidade Local de Saude Gaia/Espinho - Hospital Eduardo Santos Silva ( Site 1401) | Vila Nova de Gaia | Porto | 4434-502 | Portugal | Details | |
Inst. Portugues de Oncologia de Porto Francisco Gentil EPE ( Site 1400) | Porto | 4200-072 | Portugal | Details | ||
Spitalul Clinic Colțea ( Site 1708) | București | Bucuresti | 030171 | Romania | Details | |
Cardiomed SRL Cluj-Napoca ( Site 1701) | Cluj Napoca | Cluj | 400015 | Romania | Details | |
Institutul Oncologic Prof.Dr. Ion Chiricuta Cluj-Napoca ( Site 1702) | Cluj Napoca | Cluj | 400015 | Romania | Details | |
S.C. Radiotherapy Center Cluj S.R.L ( Site 1706) | Floresti | Cluj | 407280 | Romania | Details | |
S.C. Centrul de Oncologie Sf. Nectarie SRL ( Site 1704) | Craiova | Dolj | 200542 | Romania | Details | |
Cabinet Medical Oncomed ( Site 1707) | Timișoara | Timis | 300239 | Romania | Details | |
S.C.Focus Lab Plus S.R.L ( Site 1703) | Bucuresti | 022548 | Romania | Details | ||
Instituto Catalan de Oncologia ICO - Hospital Duran i Reynals ( Site 0700) | Hospitalet de Llobregat | Barcelona | 08908 | Spain | Details | |
HOSPITAL CLÍNIC DE BARCELONA ( Site 0707) | Barcelona | Cataluna | 08036 | Spain | Details | |
Centro Oncologico de Galicia ( Site 0706) | A Coruna | Galicia | 15009 | Spain | Details | |
Hospital General de Valencia ( Site 0703) | Valencia | Valenciana, Comunitat | 46014 | Spain | Details | |
Hospital Universitari Vall d Hebron ( Site 0701) | Barcelona | 08035 | Spain | Details | ||
Hospital Ramon y Cajal ( Site 0705) | Madrid | 28034 | Spain | Details | ||
Hospital Virgen de la Victoria ( Site 0702) | Malaga | 29010 | Spain | Details | ||
Chang Gung Memorial Hospital - Linkou Branch ( Site 1203) | Taoyuan County | Taoyuan | 333 | Taiwan | Details | |
Chang Gung Medical Foundation - Kaohsiung ( Site 1204) | Kaohsiung | 83301 | Taiwan | Details | ||
China Medical University Hospital ( Site 1205) | Taichung | 404332 | Taiwan | Details | ||
Taichung Veterans General Hospital ( Site 1206) | Taichung | 407 | Taiwan | Details | ||
National Cheng Kung University Hospital ( Site 1202) | Tainan | 70403 | Taiwan | Details | ||
National Taiwan University Hospital ( Site 1200) | Taipei | 10048 | Taiwan | Details | ||
Taipei Veterans General Hospital ( Site 1201) | Taipei | 11217 | Taiwan | Details | ||
Aberdeen Royal Infirmary ( Site 0911) | Aberdeen | Aberdeen City | AB25 2ZN | United Kingdom | Details | |
Castle Hill Hospital ( Site 0910) | Cottingham | East Riding Of Yorkshire | HU16 5JQ | United Kingdom | Details | |
The Beatson West of Scotland Cancer Centre ( Site 0909) | Glasgow | Glasgow City | G12 0YN | United Kingdom | Details | |
Guy s and St Thomas Hospital NHS Foundation Trust ( Site 0903) | London | Great Britain | SE1 9RT | United Kingdom | Details | |
University Hospital Southampton NHS Foundation Trust ( Site 0905) | Southampton | Hampshire | SO16 6YD | United Kingdom | Details | |
Royal Marsden Hospital ( Site 0902) | London | London, City Of | SW3 6JJ | United Kingdom | Details | |
Charing Cross Hospital ( Site 0908) | London | London, City Of | W6 8RF | United Kingdom | Details | |
Musgrove Park Hospital ( Site 0904) | Taunton | Somerset | TA1 5DA | United Kingdom | Details | |
Royal Marsden Hospital. ( Site 0901) | Sutton | Surrey | SM2 5PT | United Kingdom | Details | |
The Christie NHS Foundation Trust ( Site 0907) | Manchester | m20 4bx | United Kingdom | Details |