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NCT ID NCT04428151
Title Lenvatinib (E7080/MK-7902) in Combination With Pembrolizumab (MK-3475) vs. Standard Chemotherapy and Lenvatinib Monotherapy in Participants With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma That Progressed After Platinum Therapy and Immunotherapy (MK-7902-009/E7080-G000-228/LEAP-009)
Recruitment Active, not recruiting
Gender both
Phase Phase II
Variant Requirements No
Sponsors Merck Sharp & Dohme Corp.
Indications
Therapies
Age Groups: adult | senior
Covered Countries USA | ROU | NOR | ISR | GBR | FRA | ESP | DNK | CAN | BRA | AUS

Facility Status City State Zip Country Details
City of Hope ( Site 1519) Duarte California 91010 United States Details
UCLA Hematology/Oncology - Westwood (Building 100) ( Site 1568) Los Angeles California 90095 United States Details
Yale-New Haven Hospital-Yale Cancer Center ( Site 1505) New Haven Connecticut 06510 United States Details
Georgetown University Medical Center ( Site 1520) Washington District of Columbia 20007 United States Details
UF Health ( Site 1554) Gainesville Florida 32608 United States Details
Mid Florida Hematology and Oncology Center ( Site 1606) Orange City Florida 32763 United States Details
Cleveland Clinic Florida ( Site 1596) Weston Florida 33331 United States Details
Georgia Cancer Center at Augusta University ( Site 1575) Augusta Georgia 30912 United States Details
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital-Research ( Site 1521) Marietta Georgia 30060 United States Details
Memorial Health University Medical Center ( Site 1626) Savannah Georgia 31404 United States Details
Beacon Cancer Care ( Site 1599) Post Falls Idaho 83854 United States Details
Rush University Medical Center ( Site 1560) Chicago Illinois 60607 United States Details
NorthShore University HealthSystem - Evanston Hospital ( Site 1614) Evanston Illinois 60201 United States Details
IU Health Ball Memorial Hospital, Inc.-IU Health Ball Memorial Cancer Center ( Site 1612) Muncie Indiana 47303 United States Details
University of Iowa ( Site 1572) Iowa City Iowa 52242 United States Details
University of Kansas Cancer Center ( Site 1538) Westwood Kansas 66205 United States Details
Norton Hospital-Norton Cancer Institute - Downtown ( Site 1601) Louisville Kentucky 40205 United States Details
Mercy Health-Paducah Cancer Center ( Site 1623) Paducah Kentucky 42003 United States Details
Our Lady of the Lake RMC-Clinical Research ( Site 1624) Baton Rouge Louisiana 70808 United States Details
Mary Bird Perkins Cancer Center Baton Rouge ( Site 1622) Baton Rouge Louisiana 70809 United States Details
University of Maryland Greenebaum Cancer Center ( Site 1522) Baltimore Maryland 21201 United States Details
Boston Medical Center ( Site 1605) Boston Massachusetts 02118 United States Details
University of Massachusetts Chan Medical School ( Site 1616) Worcester Massachusetts 01655 United States Details
VA Ann Arbor Healthcare System ( Site 1584) Ann Arbor Michigan 48105 United States Details
Barbara Ann Karmanos Cancer Institute ( Site 1566) Detroit Michigan 48201 United States Details
Henry Ford Health System ( Site 1544) Detroit Michigan 48202 United States Details
Hattiesburg Clinic ( Site 1515) Hattiesburg Mississippi 39401 United States Details
Jackson Oncology Associates, PLLC-Clinical Trials ( Site 1625) Jackson Mississippi 39202 United States Details
Washington University School of Medicine ( Site 1500) Saint Louis Missouri 63110 United States Details
St. Vincent Frontier Cancer Center ( Site 1507) Billings Montana 59102 United States Details
University Of Nebraska Medical Center ( Site 1570) Omaha Nebraska 68105 United States Details
Oncology Hematology West P.C. dba Nebraska Cancer Specialists ( Site 1627) Omaha Nebraska 68130 United States Details
John Theurer Cancer Center at Hackensack University Medical Center ( Site 1555) Hackensack New Jersey 07601 United States Details
Rutgers Cancer Institute of New Jersey ( Site 1523) New Brunswick New Jersey 08903 United States Details
Perlmutter Cancer Center at Winthrop Oncology Hematology Associates NYU Langone Health ( Site 1597) Mineola New York 11501 United States Details
Laura and Isaac Perlmutter Cancer Center ( Site 1582) New York New York 10016 United States Details
Levine Cancer Institute ( Site 1590) Charlotte North Carolina 28204 United States Details
Duke Cancer Institute ( Site 1541) Durham North Carolina 27710 United States Details
University of Cincinnati Medical Center ( Site 1567) Cincinnati Ohio 45219 United States Details
University Hospital Cleveland ( Site 1578) Cleveland Ohio 44106 United States Details
Cleveland Clinic Main ( Site 1598) Cleveland Ohio 44195 United States Details
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive C Columbus Ohio 43210 United States Details
Oklahoma Cancer Specialists and Research Institute, LLC ( Site 1508) Tulsa Oklahoma 74146 United States Details
Gettysburg Cancer Center ( Site 1594) Gettysburg Pennsylvania 17325 United States Details
Penn State Hershey Medical Center ( Site 1561) Hershey Pennsylvania 17033 United States Details
Fox Chase Cancer Center ( Site 1502) Philadelphia Pennsylvania 19111 United States Details
Medical University of South Carolina ( Site 1579) Charleston South Carolina 29425 United States Details
St Francis Cancer Center-Research Office ( Site 1607) Greenville South Carolina 29607 United States Details
The Center For Cancer And Blood Disorders ( Site 1569) Fort Worth Texas 76104 United States Details
Utah Cancer Specialists ( Site 1621) Salt Lake City Utah 84106 United States Details
Huntsman Cancer Institute ( Site 1532) Salt Lake City Utah 84112 United States Details
Inova Schar Cancer Institute ( Site 1550) Fairfax Virginia 22031-4867 United States Details
Hematology Oncology Associates of Fredericksburg ( Site 1537) Fredericksburg Virginia 22408 United States Details
MultiCare Health System-MultiCare Oncology - Puget Sound ( Site 1609) Tacoma Washington 98405 United States Details
Medical College of Wisconsin Clinical Cancer Center ( Site 1574) Milwaukee Wisconsin 53226 United States Details
Mid North Coast Cancer Institute ( Site 0109) Port Macquarie New South Wales 2444 Australia Details
Blacktown Hospital ( Site 0101) Sydney New South Wales 2148 Australia Details
The Townsville Hospital ( Site 0107) Douglas Queensland 4814 Australia Details
Gallipoli Medical Research Ltd-GMRF CTU ( Site 0105) Greenslopes Queensland 4120 Australia Details
Royal Adelaide Hospital ( Site 0110) Adelaide South Australia 5000 Australia Details
Monash Health ( Site 0102) Clayton Victoria 3168 Australia Details
Hospital Nossa Senhora da Conceição-Centro Integrado de Pesquisa em Oncologia ( Site 0806) Porto Alegre Rio Grande Do Sul 91350-200 Brazil Details
A. C. Camargo Cancer Center ( Site 0809) Sao Paulo 01509-010 Brazil Details
Tom Baker Cancer Centre ( Site 0304) Calgary Alberta T2N 4N2 Canada Details
BC Cancer-Vancouver Center ( Site 0306) Vancouver British Columbia V5Z 4E6 Canada Details
Hamilton Health Sciences-Juravinski Cancer Centre ( Site 0307) Hamilton Ontario L8V 5C2 Canada Details
Sunnybrook Research Institute ( Site 0308) Toronto Ontario M4N 3M5 Canada Details
Instituto de Cancerología ( Site 0408) Medellin Antioquia 050025 Colombia Details
Sociedad De Oncologia Y Hematologia Del Cesar ( Site 0404) Valledupar Cesar 200001 Colombia Details
Oncomédica S.A.S ( Site 0409) Montería Cordoba 230002 Colombia Details
Administradora Country S.A.S - Clínica del Country ( Site 0407) Bogotá Cundinamarca 110221 Colombia Details
Rigshospitalet University Hospital Copenhagen ( Site 1000) Copenhagen Hovedstaden 2100 Denmark Details
Hopital La Timone ( Site 0503) Marseille Bouches-du-Rhone 13385 France Details
Centre de Cancerologie du Grand Montpellier ( Site 0508) Montpellier Herault 34070 France Details
Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne-ONCOLOGY ( Site 0510) Clermont-Ferrand Puy-de-Dome 63011 France Details
Centre de Lutte Contre le Cancer - Centre Henri Becquerel Normandie Rouen ( Site 0509) Rouen Seine-Maritime 76038 France Details
Institut Gustave Roussy ( Site 0505) Villejuif Val-de-Marne 94800 France Details
Institut Curie ( Site 0500) Paris 75005 France Details
Soroka Medical Center-Oncology ( Site 0604) Be'er Sheva 8400000 Israel Details
Rambam Health Care Campus-Oncology Division ( Site 0602) Haifa 3109601 Israel Details
Hadassah Medical Center. Ein Kerem ( Site 0601) Jerusalem 9112001 Israel Details
Chaim Sheba Medical Center ( Site 0600) Ramat Gan 5265601 Israel Details
Seoul National University Bundang Hospital ( Site 1801) Seongnam Kyonggi-do 13620 Korea, Republic of Details
Ajou University Hospital ( Site 1802) Suwon Kyonggi-do 16499 Korea, Republic of Details
Severance Hospital Yonsei University Health System ( Site 1800) Seoul 03722 Korea, Republic of Details
Samsung Medical Center ( Site 1803) Seoul 06351 Korea, Republic of Details
Oslo universitetssykehus, Radiumhospitalet ( Site 1102) Oslo 0379 Norway Details
Unidade Local de Saude Gaia/Espinho - Hospital Eduardo Santos Silva ( Site 1401) Vila Nova de Gaia Porto 4434-502 Portugal Details
Inst. Portugues de Oncologia de Porto Francisco Gentil EPE ( Site 1400) Porto 4200-072 Portugal Details
Spitalul Clinic Colțea ( Site 1708) București Bucuresti 030171 Romania Details
Cardiomed SRL Cluj-Napoca ( Site 1701) Cluj Napoca Cluj 400015 Romania Details
Institutul Oncologic Prof.Dr. Ion Chiricuta Cluj-Napoca ( Site 1702) Cluj Napoca Cluj 400015 Romania Details
S.C. Radiotherapy Center Cluj S.R.L ( Site 1706) Floresti Cluj 407280 Romania Details
S.C. Centrul de Oncologie Sf. Nectarie SRL ( Site 1704) Craiova Dolj 200542 Romania Details
Cabinet Medical Oncomed ( Site 1707) Timișoara Timis 300239 Romania Details
S.C.Focus Lab Plus S.R.L ( Site 1703) Bucuresti 022548 Romania Details
Instituto Catalan de Oncologia ICO - Hospital Duran i Reynals ( Site 0700) Hospitalet de Llobregat Barcelona 08908 Spain Details
HOSPITAL CLÍNIC DE BARCELONA ( Site 0707) Barcelona Cataluna 08036 Spain Details
Centro Oncologico de Galicia ( Site 0706) A Coruna Galicia 15009 Spain Details
Hospital General de Valencia ( Site 0703) Valencia Valenciana, Comunitat 46014 Spain Details
Hospital Universitari Vall d Hebron ( Site 0701) Barcelona 08035 Spain Details
Hospital Ramon y Cajal ( Site 0705) Madrid 28034 Spain Details
Hospital Virgen de la Victoria ( Site 0702) Malaga 29010 Spain Details
Chang Gung Memorial Hospital - Linkou Branch ( Site 1203) Taoyuan County Taoyuan 333 Taiwan Details
Chang Gung Medical Foundation - Kaohsiung ( Site 1204) Kaohsiung 83301 Taiwan Details
China Medical University Hospital ( Site 1205) Taichung 404332 Taiwan Details
Taichung Veterans General Hospital ( Site 1206) Taichung 407 Taiwan Details
National Cheng Kung University Hospital ( Site 1202) Tainan 70403 Taiwan Details
National Taiwan University Hospital ( Site 1200) Taipei 10048 Taiwan Details
Taipei Veterans General Hospital ( Site 1201) Taipei 11217 Taiwan Details
Aberdeen Royal Infirmary ( Site 0911) Aberdeen Aberdeen City AB25 2ZN United Kingdom Details
Castle Hill Hospital ( Site 0910) Cottingham East Riding Of Yorkshire HU16 5JQ United Kingdom Details
The Beatson West of Scotland Cancer Centre ( Site 0909) Glasgow Glasgow City G12 0YN United Kingdom Details
Guy s and St Thomas Hospital NHS Foundation Trust ( Site 0903) London Great Britain SE1 9RT United Kingdom Details
University Hospital Southampton NHS Foundation Trust ( Site 0905) Southampton Hampshire SO16 6YD United Kingdom Details
Royal Marsden Hospital ( Site 0902) London London, City Of SW3 6JJ United Kingdom Details
Charing Cross Hospital ( Site 0908) London London, City Of W6 8RF United Kingdom Details
Musgrove Park Hospital ( Site 0904) Taunton Somerset TA1 5DA United Kingdom Details
Royal Marsden Hospital. ( Site 0901) Sutton Surrey SM2 5PT United Kingdom Details
The Christie NHS Foundation Trust ( Site 0907) Manchester m20 4bx United Kingdom Details
*Shaded cells indicate that there was no data available from clinicaltrials.gov for the field