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NCT ID NCT04459715
Title A Study of Xevinapant (Debio 1143) in Combination With Platinum-Based Chemotherapy and Standard Fractionation Intensity-Modulated Radiotherapy in Participants With Locally Advanced Squamous Cell Carcinoma of the Head and Neck, Suitable for Definitive Chemoradiotherapy (TrilynX)
Recruitment Terminated
Gender both
Phase Phase III
Variant Requirements Yes
Sponsors EMD Serono Research & Development Institute, Inc.
Indications
Therapies
Age Groups: adult | senior
Covered Countries USA | POL | ITA | ISR | HUN | GRC | GBR | FRA | ESP | DEU | CZE | CHE | CAN | BRA | BEL | AUT | AUS | ARG

Facility Status City State Zip Country Details
The University of Alabama at Birmingham - Hazelrig-Salter Radiation Oncology Center (HSROC) Birmingham Alabama 35233 United States Details
Banner MD Anderson Cancer Center Gilbert Arizona 85234 United States Details
University of Arizona Cancer Center Tucson Arizona 85724 United States Details
UC San Diego Moores Cancer Center La Jolla California 92093 United States Details
Regents of the University of California San Francisco California 94158 United States Details
UCSF San Francisco California 94158 United States Details
The Oncology Institute of Hope & Innovation Whittier California 90603 United States Details
University of Colorado at Denver and Health Sciences Center Aurora Colorado 80045 United States Details
Yale Cancer Center New Haven Connecticut 06519 United States Details
Lombardi Comprehensive Cancer Center, Georgetown University Medical Center Washington District of Columbia 20007 United States Details
Moffitt Cancer Center Tampa Florida 33612 United States Details
ASCLEPES Research Centers Weeki Wachee Florida 34607 United States Details
Columbus Regional Research Institute Columbus Georgia 31904 United States Details
IACT Health, John B. Amos Cancer Center Columbus Georgia 31904 United States Details
Inventa Center for Cancer Research At Fort Wayne Medical Oncology and Hematology Fort Wayne Indiana 46804 United States Details
Ashland-Bellefonte Cancer Center Ashland Kentucky 41101 United States Details
Norton Cancer Institute, Louisville, Kentucky, Brownsboro Hospital Campus Louisville Kentucky 40241 United States Details
Massachusetts General Hospital Boston Massachusetts 02114-2696 United States Details
Beth Israel Deaconess (BI Lahey)/Harvard Cancer Center Boston Massachusetts 02215 United States Details
Dana-Farber Cancer Institute Boston Massachusetts 02215 United States Details
University South Hospital Ann Arbor Michigan 48109-9001 United States Details
Henry Ford Health System Detroit Michigan 48202 United States Details
Karmanos Cancer institute Detroit Michigan 48302 United States Details
University of Missouri - Ellis Fischel Cancer Center Columbia Missouri 65212 United States Details
MidAmerica Cancer Care Kansas City Missouri 64114 United States Details
Washington University School of Medicine Saint Louis Missouri 63110 United States Details
Comprehensive Cancer Center of Nevada (Southern Hills) (USA) Las Vegas Nevada 89148 United States Details
Comprehensive Cancer Centers of Nevada Las Vegas Nevada 89169 United States Details
NYU Langone Hospital-Long Island Oncology Mineola New York 11501 United States Details
Laura and Isaac Perlmutter Cancer Center at NYU Langone Health New York New York 10016 United States Details
NYU Grossman School of Medicine New York New York 10016 United States Details
Wake Forest University School of Medicine Winston-Salem North Carolina 27157 United States Details
University of Cincinnati Medical Center Cincinnati Ohio 45267 United States Details
University Hospital Cleveland Medical Center Cleveland Ohio 44106 United States Details
Cleveland Clinic Cleveland Ohio 44195 United States Details
Ohio State University Columbus Ohio 43210 United States Details
University of Oklahoma Health Sciences Center- Stephenson Cancer Center Oklahoma City Oklahoma 73104 United States Details
Providence Portland Medical Center Portland Oregon 97213 United States Details
Gettysburg Cancer Center Gettysburg Pennsylvania 17325 United States Details
Fox Chase Cancer Center Philadelphia Pennsylvania 19111 United States Details
Medical University of South Carolina- Hollings Cancer Center Charleston South Carolina 29425 United States Details
MD Anderson Houston Texas 77030 United States Details
IHO Corporation/Utah Cancer Specialists Salt Lake City Utah 84106 United States Details
University of Virginia Medical Center Charlottesville Virginia 22908 United States Details
Hospital Aleman Buenos Aires Argentina Details
Instituto Medico Especialazado Alexander Fleming Buenos Aires Argentina Details
Clinica Universitaria Reina Fabiola Cordoba Argentina Details
Instituto de Oncologia de Rosario Santa Fe Argentina Details
Clinica Viedma Viedma Argentina Details
Ashford Cancer Centre Research, Tennyson Centre Adelaide Australia Details
St Vincents Hospital Darlinghurst Australia Details
St Vincents Hospital Melbourne Fitzroy Australia Details
Peter MacCallum Cancer Centre Melbourne Australia Details
Wollongong Hospital Wollongong Australia Details
Princess Alexandra Hospital, Cancer Trials Unit Woolloongabba Australia Details
Klinische Abteilung fur Allgemeine HNO Universitatsklinik fur Hals-, Nasen- und Ohrenheilkunde Graz Austria Details
Landeskrankenhaus Salzburg Salzburg Austria Details
Universitätsklinik für Innere Medizin III der PMU Salzburg Austria Details
Medical University of Vienna, Department of Medicine I, Division of Oncology Vienna Austria Details
Cliniques universitaires Saint-Luc Bruxelles Belgium Details
Grand Hopital de Charleroi Charleroi Belgium Details
Universitair Ziekenhuis Antwerpen Edegem Belgium Details
Universitair Ziekenhuis Gent UZ Gent Gent Belgium Details
Hopital de Jolimont, Rue Ferrer La Louvière Belgium Details
UZ Leuven, Radiotherapy & Oncology Leuven Belgium Details
Centre Hospitalier de l'Ardenne (CHA) Libramont Belgium Details
CHU UCL Namur Site Sainte Elisabeth Namur Belgium Details
A.Z. Nikolaas Sint-Niklaas Belgium Details
GZA Sint-Augustinus Wilrijk Belgium Details
Fundação Pio XII- Hospital de Cancer de Barretos, Rua Antenor Duarte Vilela Barretos Brazil Details
Hospital de Caridade de Ijui, Avenida David Jose Martins Ijuí Brazil Details
Liga Norte Riograndense Contra o Câncer, Avenida Miguel Castro Natal Brazil Details
Centro Gaúcho Integrado, Rua Costa Porto Alegre Brazil Details
Hospital Santa Rita Centro de Pesquisa Clínica Novos Tratamentos Em Câncer Porto Alegre Brazil Details
Hospital Santa Rita, Centro de Pesquisa Clínica Novos Tratamentos Em Câncer Porto Alegre Brazil Details
National Cancer Institute Rio De Janeiro Brazil Details
CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia - FMABC - Faculdade de Medicina do ABC Santo André Brazil Details
Hospital de Base de Sao Jose do Rio Preto, Av. Brigadeiro Faria Lima São José Do Rio Preto Brazil Details
Instituto do Cancer do Estado de Sao Paulo (ICESP) São Paulo Brazil Details
Oswaldo Cruz German Hospital São Paulo Brazil Details
London Regional Cancer Program, London Health Sciences Centre London Canada Details
CHU Montréal Montreal Canada Details
CIUSSS de l'Est de l'Ile de Montreal - Hopital Maisonneuve-Rosemont Montreal Canada Details
Hopital Maisonneuve-Rosemont Montreal Canada Details
CHU de Quebec-Université Laval Québec Canada Details
Sunnybrook Research Institute Toronto Canada Details
Beijing Cancer Hospital Beijing China Details
Peking Union Medical College Hospital Beijing China Details
Jilin Cancer Hospital Changchun China Details
Hunan Cancer Hospital Changsha China Details
Xiangya Hospital Central South University Changsha China Details
West China Hospital of Sichuan University Chengdu China Details
Fujian Cancer Hospital Fuzhou China Details
The 5th Affiliated Hospital of Sun yet-sen university Guangdong China Details
The 2nd Affiliated Hospital of Zhejiang University School of Medicine Hangzhou China Details
Zhejiang Province Cancer Hospital Hangzhou China Details
Harbin Medical University Cancer Hospital Harbin China Details
Affiliated Tumor Hospital of Guangxi Medical University Nanning China Details
Lin Yi Cancer Hospital Shandong China Details
Fudan University Shanghai Cancer Center Shanghai China Details
Shanghai Ninth People's Hospital Shanghai China Details
Shantou University Cancer Hospital Shantou China Details
Liaoning Cancer Hospital & institute Shenyang China Details
Tianjin Medical University Cancer Institute & Hospital Tianjin China Details
Tongji Hospital/Tongji Medical College, Huazhong University of Science Wuhan China Details
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan China Details
Henan Cancer Hospital Zhengzhou China Details
University Hospital hradec Kralové Hradec Králové Czechia Details
Fakultni Nemocnice Ostrava Ostrava-Poruba Czechia Details
Hospital Na Bulovce Prague Czechia Details
KOC KNTB a.s. Zlín Zlín Czechia Details
CHU Amiens Picardie - Hopital Sud Amiens France Details
Institut de Cancérologie de l Ouest (ICO) Angers France Details
Institut Sainte Catherine Avignon Cedex 9 France Details
Centre hospitalier Universitaire de Bordeaux Bordeaux France Details
CHRU de Brest Hopital Morvan Brest France Details
Centre Jean Perrin CLCC Clermont Ferrand France Details
CHU de Grenoble Grenoble Cedex 9 France Details
Centre Guillaume Le Conquerant le Havre France Details
Clinique Victor Hugo Le Mans France Details
Centre hospitalier Libourne Libourne France Details
Centre Oscar Lambret Lille France Details
Hôpital du Scorff Lorient France Details
Centre Leon Berard Lyon France Details
Service d'Oncologie Médicale, CHU Timone Marseille France Details
Hôpital Nord Franche Comté Montbeliard France Details
Institut Regional du Cancer de Montpellier Montpellier France Details
LHopital prive du Confluent Nantes Nantes Cedex 2 France Details
CCConcorde (GCS) Neuilly sur Seine France Details
Centre Antoine Lacassagne Nice France Details
CHU Nimes Nimes France Details
Institut Curie Paris France Details
Centre Eugène Marquis Rennes Cedex France Details
Centre Henri Becquerel CLCC Rouen Cedex France Details
CHP Saint Gregoire FINESS Saint Gregoire France Details
Institut de Cancérologie de l'Ouest - Site Saint Herblain Saint Herblain France Details
ICANS Strasbourg France Details
Institut Claudius Regaud - IUCT-O Toulouse France Details
CHU de Tours Tours France Details
The Public Hospital L'Institut de Cancerologie de Lorraine Vandoeuvre les Nancy France Details
Institut Gustave Roussy - Service de radiotherapie Villejuif France Details
Evex Hospitals Oncology Center Kutaisi Georgia Details
Academician Fridon Todua Medical Center-Ltd Research Institute of Clinical Medicine Tbilisi Georgia Details
Cancer Research Cent 4 Tbilisi Georgia Details
Institute of Clinical Oncology Tbilisi Georgia Details
JSC "Evex Hospitals" Tbilisi Georgia Details
LEPL First University Clinic of Tbilisi State Medical University Tbilisi Georgia Details
New Hospitals Tbilisi Georgia Details
Simon Khechinashvili University Clinic Tbilisi Georgia Details
CAMPUS CHARITÉ MITTE, Klinik f.Strahlentherapie Berlin Germany Details
Charité - Universitätsmedizin Berlin Campus Virchow Berlin Germany Details
Strahlenklinik des Uni-Klinikums Erlangen Germany Details
Department of radiation oncology, University Hospital Essen Essen Germany Details
Univesitätsklinikum Essen (AöR) Klinikum und Poliklinik für Strahlentherapie Essen Germany Details
Universitätsklinikum Hamburg-Eppendorf Hamburg Germany Details
Universitaetsklinikum Jena - Klinik fuer Hals - Nasen und Ohrenheilkunde HNO Jena Germany Details
University Medical Center Schleswig-Holstein, Campus Kiel Kiel Germany Details
Universitatsklinikum Leipzig AoR, Klinik für Strahlentherapie Leipzig Germany Details
Universitaetsmedizin Mannheim UMM, Klinik fuer Hals-Nasen-Ohrenheilkunde Kopf- und Halschirurgie Mannheim Germany Details
Universitaetsklinikum Regensburg Regensburg Germany Details
Universitaetsmedizin Rostock Rostock Germany Details
Agioi Anargiroi General Oncology Hospital of Kifissia Athens Greece Details
Attikon University Hospital Athens Greece Details
Theagenio Anticancer Hospital Thessaloníki Greece Details
Orszagos Onkologiai Intezet Sugarterapias Osztaly Budapest Hungary Details
Uzsoki Utcai Korhaz Onkologiai Osztaly Budapest Hungary Details
Petz Aladár Megyei Kórház Onkoradiológiai Osztály Győr Hungary Details
Pecsi Tudomanyegyetem Klinikai Kozpont Onkoterapias Intazet Pécs Hungary Details
Szegedi Tudományegyetem ÁOK Onkoterápiás Klinika Szeged Hungary Details
Rambam Healthcare Campus Haifa Israel Details
Research Fund of the Hadassah Medical Organization Jerusalem Israel Details
Rabin Medical Center Petach Tiqva Israel Details
Sheba Medical Center Ramat Gan Israel Details
Centro di Riferimento Oncologico Aviano Italy Details
Azienda Socio Sanitaria Territoriale (ASST) degli Spedali Civili di Brescia Brescia Italy Details
Istituto di Candiolo IRCCS Candiolo Italy Details
Azienda Sanitaria Ospedaliera Santa Croce e Carle - Oncologia Medica -Ospedale Carle Cuneo Italy Details
Azienda Ospedaliero-Universitaria Careggi Firenze Italy Details
IRCCS AOU San Martino Genova Italy Details
Ospedale "Vito Fazzi" Lecce Lecce Italy Details
Az. USL 6 Ospedali Riuniti-Ospedale di Livorno Livorno Italy Details
IRCCS - Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) Meldola Italy Details
IRCCS-Istituto Europeodi Oncologia The European Institute of Oncology IEO Milan Italy Details
Istituto Nazionale dei Tumori Milan Italy Details
Policlinico di Modena Modena Italy Details
AORN Ospedale dei Monaldi Napoli Italy Details
AOU "Luigi Vanvitelli" Napoli Italy Details
Istituto Nazionale Tumori (INT) IRCCS Fondazione "G. Pascale" Napoli Italy Details
Istituto Oncologico Veneto Irccs Padova Italy Details
Azienda Ospedaliero Universitaria di Parma Parma Italy Details
Fondazione Policlinico Universitario Agostino Gemelli Rome Italy Details
ASL2_Presidio Ospedaliero San Paolo Savona Italy Details
National Cancer Center Hospital East Chiba Japan Details
National Cancer Center Hospital Chuo-ku Tokyo Japan Details
Saitama Medical University International Medical Center Hidaka Japan Details
Hyogo Cancer Center Hyogo Japan Details
University Hospital Kyoto Prefectural University of Medicine Kamigyo-ku Japan Details
Tokai University Hospital Kanagawa Japan Details
Hokkaido University Hospital Kita-Ku Japan Details
Okayama University Hospital Kita-ku Japan Details
Kobe University Hospital Kobe Japan Details
Cancer Institute Hospital of JFCR Koto-ku Japan Details
National Hospital Organization Shikoku Cancer Center Matsuyama Japan Details
Shizuoka Cancer Center Nagaizumi-cho Japan Details
Osaka International Cancer Institute Osaka Japan Details
Tokyo Medical University Hospital Tokyo Japan Details
Pusan National University Hospital Busan Korea, Republic of Details
National Cancer Center Hematologic Oncology Goyang-si Korea, Republic of Details
National Cancer Center Goyang-si Korea, Republic of Details
Asan Medical Center, Asian Cacer Center Seoul Korea, Republic of Details
Asan Medical Center Seoul Korea, Republic of Details
KonKuk University Medical Center Seoul Korea, Republic of Details
Korea University Anam Hospital Seoul Korea, Republic of Details
Seoul National University Boramae Medical Center Seoul Korea, Republic of Details
Pusan National University Yangsan Hospital, Oncol & Hematology Yangsan Korea, Republic of Details
Uniwersyteckie Centrum Kliniczne - Klinika Onkologii i Radioterapii Gdańsk Poland Details
Szpitale Pomorskie Sp. z o.o. Gdynia Poland Details
Centrum Onkologii- Instytut im. Marii Sklodowskiej-Curie Oddzial w Gliwicach Gliwice Poland Details
SP ZOZ MSWiA z W-M CO w Olsztynie Olsztyn Poland Details
NZOZ Provita Prolife Centrum Medyczne Łódź Poland Details
Centro Clinico Academico Braga Portugal Details
Hospital de Braga Braga Portugal Details
Instituto Português de Oncologia de Coimbra Francisco Gentil, EPE Coimbra Portugal Details
Centro Hospitalar Universitário do Algarve - Hospital de Faro (PRT) Faro Portugal Details
Centro Hospitalar Universitário Lisboa Norte Lissabon Portugal Details
Centro Hospitalar de Vila Nova de Gaia/Espinho Porto Portugal Details
Centro Hospitalar Universitario São João Porto Portugal Details
Hospital Pedro Hispano Porto Portugal Details
Instituto Portugues de Oncologia Porto Francisco Gentil, E.P.E Porto Portugal Details
State Autonomous Healthcare Institution "Republican Clinical Oncological Dispensary of the Ministry of Healthcare of the Republic of Tatarstan" Kazan Russian Federation Details
Krasnoyarsk Regional Clinical Oncological Dispensary named after A.I.Kryzhanovsky Krasnoyarsk Russian Federation Details
Kursk Regional Clinical Oncology Dispensary Kursk Russian Federation Details
FGBU N.N.Blokhin Russian Cancer Research Center Moscow Russian Federation Details
EuroCityClinic Saint Petersburg Russian Federation Details
Saint- Petersburg Clinical Research Center of Specialized Types of Medical Care (Oncology) Saint Petersburg Russian Federation Details
FSBI National Med Research Cancer Center N.N. Petrov Saint-Petersburg Russian Federation Details
Republican Clinical Oncological Dispensary of Bashkortostan Ufa Russian Federation Details
State Budgetary Healthcare Institution Republican Clinical Oncology Dispensary (RUS) Ufa Russian Federation Details
State Budgetary Institution of Healthcare of Yaroslavl region Clinical oncology hospital Yaroslavl Russian Federation Details
Fundacion Centro Oncologico de Galicia (COG) "Jose Antonio Quiroga y Pineyro" A Coruña Galicia Spain Details
Fundacin Oncolgico de Galicia Jos Antonio Quiroga y Pieyro A Coruna Spain Details
Hospital Clinic Barcelona Barcelona Spain Details
Hospital del Mar Barcelona Spain Details
Hospital Universitari Vall d'Hebron Barcelona Spain Details
Institut Català d'Oncologia Badalona Barcelona Spain Details
Institut Català d'Oncologia, Hospital Duran Barcelona Spain Details
Institut Universitari Dexeus-Quiron (ESP) Barcelona Spain Details
Hospital Reina Sofía Cordoba Spain Details
Institut Català d'Oncologia Girona Spain Details
Hospital Universitario Insular de Gran Canaria Las Palmas de Gran Canaria Spain Details
Clinica Universidad de Navarra Madrid Spain Details
Hospital 12 de Octubre Madrid Spain Details
Hospital Clinico San Carlos Madrid Spain Details
Hospital Ramon y Cajal Madrid Spain Details
Hospital Universitario HM Sanchinarro Madrid Spain Details
Hospital Universitario La Paz Madrid Spain Details
Althaia, Xarxa Assistencial Manresa Spain Details
Fundacio Althaia Manresa Spain Details
Hospital Civil (Hospital Regional Universitario) Málaga Spain Details
Clinica Universidad de Navarra Pamplona Spain Details
Hospital Universitario Marqués de Valdecilla. Santander Santander Spain Details
Fundacion Investigacion Hospital General Universitario de Valencia FiHgU (ESP) Valencia Spain Details
Hospital Universitario La Fe Valencia Spain Details
IVO Valencia Spain Details
Inselspital, Bern University Hospital, Universitätsklinik für Radio-Onkologie Bern Switzerland Details
Hopitaux Universitaires de Geneve Geneve Switzerland Details
Centre Hospitalier Universitaire Vaudois Lausanne Lausanne Switzerland Details
Chang-Gung Memorial Hospital-Kaohsiung Kaohsiung City Taiwan Details
Kaohsiung Medical University Memorial Hospital Kaohsiung Taiwan Details
Taichung Veterans General Hospital Taichung City Taiwan Details
China Medical University Hospital Taichung Taiwan Details
National Taiwan University Hospital Taipei Taiwan Details
Taipei Veterans General Hospital (VGHTP) Taipei Taiwan Details
Chang Gung Medical Foundatoin Linkou Chang Gung Memorial Hospital Taoyuan City Taiwan Details
Medical center ASKLEPION LLC Khodosivka Ukraine Details
Kiev City Clinical Oncology Centre Kiev Ukraine Details
Medical center of Yuriy Spizhenko, Soborna Vulytsia Kyiv Ukraine Details
Aberdeen Royal infirmary, Dept. of Oncology Aberdeen United Kingdom Details
Royal Marsden NHS Foundation Trust Chelsea United Kingdom Details
NHS Greater Glasgow and Clyde Glasgow United Kingdom Details
Royal Surrey County Hospital Guildford United Kingdom Details
Charing Cross Hospital London United Kingdom Details
The Christie NHS Foundation Trust Manchester United Kingdom Details
Mount Vernon Cancer Centre Northwood United Kingdom Details
Nottingham University Hospitals NHS Trust Nottingham United Kingdom Details
University Hospital Southampton NHS Foundation Trust Southampton United Kingdom Details
The Royal Marsden NHS Foundation Trust - Sutton Sutton United Kingdom Details
Clatterbridge Cancer Centre NHS Foundation Trust Wirral United Kingdom Details
*Shaded cells indicate that there was no data available from clinicaltrials.gov for the field