splenic marginal zone lymphoma
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ID DOID:0050750
Name splenic marginal zone lymphoma
Definition A marginal zone B-cell lymphocyte located_in the spleen comprised of B-cells in place of white pulp.
Source DiseaseOntology.org
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Path disease disease of cellular proliferation cancer organ system cancer hematologic cancer lymphoma non-Hodgkin lymphoma B-cell lymphoma marginal zone lymphoma splenic marginal zone lymphoma

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
BRAF mutant N/A splenic marginal zone lymphoma not applicable detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03198026 Phase II Ibrutinib + Obinutuzumab Obinutuzumab and Ibrutinib as Front Line Therapy in Treating Patients With Indolent Non-Hodgkin's Lymphomas Active, not recruiting USA 0
NCT03322865 Phase II Obinutuzumab Obinutuzumab in Marginal Zone Lymphoma Active, not recruiting DEU 0
NCT03474744 Phase II Copanlisib + Rituximab Copanlisib and Rituximab in Marginal Zone Lymphoma Patients Active, not recruiting DEU | AUT 0
NCT03601819 Phase I Pacritinib Pacritinib in Relapsed/Refractory Lymphoproliferative Disorders Terminated USA 0
NCT03696784 Phase I Rimiducid Bendamustine + Fludarabine + iC9-CAR.19-IL15-Transduced CB-NK Anti-CD19 CAR-T Cells With Inducible Caspase 9 Safety Switch for B-cell Lymphoma Active, not recruiting USA 0
NCT03697512 Phase II Ibrutinib + Rituximab MALIBU Trial - Combination of Ibrutinib and Rituximab in Untreated Marginal Zone Lymphomas (MALIBU) Active, not recruiting ITA | FRA | CHE | BEL 1
NCT04186520 Phase Ib/II LV20.19 CAR-T cells CAR-20/19-T Cells in Patients With Relapsed Refractory B Cell Malignancies Recruiting USA 0
NCT04223765 Phase I Bendamustine + CAR.k.28 cells + Fludarabine CAR.k.28 cells + Cyclophosphamide + Fludarabine Study of Kappa Chimeric Antigen Receptor (CAR) T Lymphocytes Co-Expressing the Kappa and CD28 CARs for Relapsed/Refractory Kappa+ Non-Hodgkin Lymphoma Recruiting USA 0
NCT04277637 Phase I Sonrotoclax + Zanubrutinib Sonrotoclax Obinutuzumab + Sonrotoclax + Zanubrutinib Study of Bcl-2 Inhibitor Sonrotoclax (BGB-11417) in Participants With Mature B-Cell Malignancies Active, not recruiting USA | NZL | ITA | GBR | ESP | DEU | AUS 0
NCT04680052 Phase III Lenalidomide + Rituximab Lenalidomide + Rituximab + Tafasitamab-cxix A Phase 3 Study to Assess Efficacy and Safety of Tafasitamab Plus Lenalidomide and Rituximab Compared to Placebo Plus Lenalidomide and Rituximab in Patients With Relapsed/Refractory (R/R) Follicular Lymphoma or Marginal Zone Lymphoma. (InMIND) Active, not recruiting USA | TUR | SWE | POL | NOR | NLD | ITA | ISR | IRL | HUN | GRC | GBR | FRA | FIN | ESP | DNK | DEU | CZE | CHE | CAN | BEL | AUT | AUS 5
NCT04842877 Phase II DS-3201b Study of Valemetostat Tosylate as a Single Agent in Patients With Relapse/Refractory B-cell Lymphoma Active, not recruiting FRA | BEL 0
NCT05338346 Phase I ATG-018 A Study of ATG-018 (ATR Inhibitor) Treatment in Patients With Advanced Solid Tumors and Hematological Malignancies (ATRIUM) Terminated AUS 0
NCT05424822 Phase I JNJ-80948543 A Study of JNJ-80948543, a T Cell Redirecting Antibody, in Non-Hodgkin Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL) Active, not recruiting USA | POL | ISR | FRA | DNK | AUS 2
NCT05735834 Phase III Rituximab Rituximab + Zanubrutinib Comparison Between Rituximab Plus Zanubrutinib Versus Rituximab Monotherapy in Untreated SMZL Patients (RITZ) Active, not recruiting SWE | NOR | ITA | GBR | FRA | ESP | CHE | AUT 0
NCT06006117 Phase III Lenalidomide + Rituximab Lenalidomide + Mosunetuzumab-axgb Cyclophosphamide + Doxorubicin + Prednisone + Rituximab + Vincristine Sulfate Bendamustine + Rituximab Mosunetuzumab-Lenalidomide Versus Investigator Choices in Patients With Relapsed or Refractory Marginal Zone Lymphoma Recruiting ITA | FRA | DEU | BEL 1
NCT06300528 Phase II Pemigatinib Pemigatinib for the Treatment of Patients With Relapsed or Refractory Mantle Cell Lymphoma or Marginal Zone Lymphoma Active, not recruiting USA 0
NCT06350318 Phase II Rituximab + Zanubrutinib Rituximab and Zanubrutinib in Patients With Indolent B-cell Lymphomas Recruiting USA 0
NCT06378190 Phase Ib/II TranspoCART19 Treatment of Relapsed or Refractory B-cell Lymphoma With Chimeric Antigen Receptor (CAR) T-cell Therapy Produced by a New Technology (TranspoCART19) Recruiting ESP 0
NCT06796998 Phase II Epcoritamab-bysp Epcoritamab in Patients With Newly Diagnosed Marginal Zone Lymphoma (MZL) Recruiting USA 0
NCT06824701 Phase I Obinutuzumab + Rituximab + Tazemetostat + Zanubrutinib Tazemetostat in Combination With Zanubrutinib and Anti-CD20 Monoclonal Antibody in Relapsed or Refractory B-cell Non-Hodgkin Lymphoma (TARZAN) Active, not recruiting USA 0
NCT07583810 Phase II ARQ 531 + Rituximab Non-covalent BTK Inhibitor Nemtabrutinib in Combination With the CD20 Monoclonal Antibody Rituximab for the Treatment of Marginal Zone Lymphoma Recruiting USA 0