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ID | DOID:50751 |
Name | T-cell large granular lymphocyte leukemia |
Definition | A T-cell acute lymphocytic leukemia that exhibits an unexplained, chronic (greater than 6 months) elevation in large granular lymphocytes (LGLs) in the peripheral blood. |
Source | DiseaseOntology.org |
Alt Ids | |
Path | disease disease of cellular proliferation cancer organ system cancer hematologic cancer leukemia lymphoid leukemia acute leukemia acute lymphoblastic leukemia T-cell acute lymphoblastic leukemia T-cell large granular lymphocyte leukemia |
Molecular Profile | Therapy | Indication/Tumor Type | Response Type | Profile Response Detail |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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NCT02512497 | Phase I | Romidepsin Busulfan + Fludarabine + Romidepsin | Romidepsin Maintenance After Allogeneic Stem Cell Transplantation | Active, not recruiting | USA | 0 |
NCT03239392 | Phase Ib/II | BNZ-1 | A Dose-Ranging Study of IV BNZ-1 in LGL Leukemia or Refractory CTCL | Completed | USA | 0 |
NCT03829540 | Phase I | CD4CAR | CD4CAR for CD4+ Leukemia and Lymphoma | Recruiting | USA | 0 |
NCT05010005 | Phase I | Duvelisib + Ruxolitinib | A Study of Ruxolitinib and Duvelisib in People With Lymphoma | Active, not recruiting | USA | 0 |
NCT05225584 | Phase I | KT-333 | Safety, PK, PD, Clinical Activity of KT-333 in Adult Patients With Refractory Lymphoma, Large Granular Lymphocytic Leukemia, Solid Tumors | Active, not recruiting | USA | 0 |
NCT05316116 | Phase I | Siltuximab | Siltuximab in Large Granular Lymphocytic Leukemia (LGLL) | Recruiting | USA | 0 |
NCT05475925 | Phase Ib/II | DR-01 | A Study of DR-01 in Subjects With Large Granular Lymphocytic Leukemia or Cytotoxic Lymphomas | Recruiting | USA | ITA | FRA | ESP | DEU | AUS | 3 |
NCT05532722 | Phase Ib/II | ABC008 | ABC008 in Subjects With T-cell Large Granular Lymphocytic Leukemia (T-LGLL) | Active, not recruiting | USA | 0 |
NCT05592015 | Phase II | Ruxolitinib | Ruxolitinib for the Treatment of T-Cell Large Granular Lymphocytic Leukemia | Recruiting | USA | 0 |