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ID DOID:7154
Name anaplastic oligodendroglioma
Definition An oligodendroglioma that is characterized by focal or diffuse malignant morphologic features (prominent nuclear pleomorphism, mitoses, and increased cellularity).
Source DiseaseOntology.org
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Path disease disease of cellular proliferation cancer cell type cancer high grade glioma oligodendroglioma anaplastic oligodendroglioma

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
BRAF V600E Dabrafenib + Trametinib anaplastic oligodendroglioma sensitive detail...
BRAF V600E Cobimetinib + Vemurafenib anaplastic oligodendroglioma sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05429502 Phase Ib/II Ribociclib + Temozolomide + Topotecan Study of Efficacy and Safety of Ribociclib (LEE011) in Combination With Topotecan and Temozolomide (TOTEM) in Pediatric Patients With Relapsed or Refractory Neuroblastoma and Other Solid Tumors Recruiting USA | ITA | GBR | FRA | ESP | DEU | AUS 1
NCT05503797 Phase II Cobicistat + PLX8394 PLX8394 A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations Recruiting USA | SWE | ITA | GBR | FRA | ESP | DEU | CAN 1
NCT05698524 Phase I Abexinostat + Temozolomide A Study of Temodar With PCI-24781 for Patients With Recurrent Glioma Recruiting USA 0
NCT05887882 Phase I TGF-beta-imprinted NK cells Intra-Tumoral Injections of Natural Killer Cells for Recurrent Malignant Brain Tumors (PNOC028) Recruiting USA 0
NCT06011109 Phase Ib/II Bevacizumab APG-157 Treatment of Patients With Recurrent High-Grade Glioma With APG-157 and Bevacizumab Recruiting USA 0
NCT06413706 Phase II Abemaciclib + Temozolomide Temozolomide A Study Comparing Abemaciclib Plus Temozolomide to Temozolomide Monotherapy in Children and Young Adults With High-grade Glioma Following Radiotherapy Not yet recruiting USA | ROU | ITA | FRA | ESP | DNK | BEL 1
NCT06463184 Phase I Xevinapant Study to Assess Xevinapant in Preoperative Subjects With Recurrent High-Grade Glioma (rHGG) Recruiting USA 0
NCT06501911 Phase I Bicalutamide A Study of Bicalutamide With Brain Re-irradiation to Treat Recurrent/Progressive High Grade Glioma Not yet recruiting USA 0