Therapy Detail

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Therapy Name Bicalutamide
Synonyms
Therapy Description

Casodex (bicalutamide) is an androgen-receptor antagonist that binds androgen receptors and inhibits androgen binding, therefore inhibits AR-dependent growth of tumor cells (PMID: 9428389). Casodex (bicalutamide) is approved, in combination with a luteinizing hormone-releasing hormone (LHRH) analog, for metastatic carcinoma of the prostate (FDA.gov).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Bicalutamide Casodex Hormone - Anti-androgens 54 Casodex (bicalutamide) is an androgen-receptor antagonist that binds androgen receptors and inhibits androgen binding, therefore inhibits AR-dependent growth of tumor cells (PMID: 9428389). Casodex (bicalutamide) is approved, in combination with a luteinizing hormone-releasing hormone (LHRH) analog, for metastatic carcinoma of the prostate (FDA.gov).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03678025 Phase III Docetaxel Nilutamide Triptorelin Bicalutamide Leuprolide Degarelix Goserelin Flutamide Prednisone Abiraterone Histrelin acetate Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer Recruiting USA | CHE 3
NCT03147196 Phase II Bicalutamide + Raloxifene Raloxifene Bicalutamide Bicalutamide and Raloxifene Hydrochloride in Treating Patients With Prostate Cancer Undergoing Surgery Withdrawn 0
NCT05050084 Phase III Buserelin Relugolix Degarelix Goserelin Leuprolide Histrelin acetate Triptorelin Darolutamide + Goserelin Bicalutamide Darolutamide + Degarelix Darolutamide + Leuprolide Darolutamide + Triptorelin Buserelin + Darolutamide Darolutamide + Histrelin acetate Flutamide Darolutamide + Relugolix Two Studies for Patients With Unfavorable Intermediate Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a Higher Gene Risk Score Recruiting USA | CAN 0
NCT01420250 Phase I Bicalutamide Cabazitaxel Cabazitaxel With Radiation and Hormone Therapy for Prostate Cancer Completed USA 0
NCT04787744 Phase II Goserelin Degarelix Relugolix Nilutamide Triptorelin Histrelin acetate Docetaxel + Prednisone Leuprolide Apalutamide Abiraterone + Prednisone Flutamide Abiraterone + Methylprednisolone Bicalutamide Docetaxel Enzalutamide Veterans Affairs Seamless Phase II/III Randomized Trial of STAndard Systemic theRapy With or Without PET-directed Local Therapy for Oligometastatic pRosTate Cancer (VA STARPORT) Recruiting USA 0
NCT02582749 Phase II Bicalutamide + Radium Ra 223 dichloride Bicalutamide Androgen Deprivation Therapy +/- Radium-223 Dichloride in Metastatic Prostate Cancer With Bone Metastases Terminated USA 0
NCT02058706 Phase II Goserelin Bicalutamide Enzalutamide Leuprolide LHRH Analogue Therapy With Enzalutamide or Bicalutamide in Treating Patients With Metastatic Hormone Sensitive Prostate Cancer Completed USA 0
NCT06018116 Phase II Bicalutamide A Canadian Phase II Trial of Bicalutamide in Patients Receiving Maintenance Avelumab for Metastatic Urothelial Cancer (CANUCK-01) Withdrawn CAN 0
NCT02059213 Phase II Goserelin Palbociclib Bicalutamide Leuprolide A Phase II Study of Androgen Deprivation Therapy With or Without PD 0332991 in RB-Positive Metastatic Prostate Cancer Completed USA 0
NCT00541047 Phase III Leuprolide Goserelin Bicalutamide Radiation Therapy and Androgen Deprivation Therapy in Treating Patients Who Have Undergone Surgery for Prostate Cancer (RADICALS) Completed GBR | CAN 0
NCT02799706 Phase III Flutamide Degarelix Bicalutamide Trial Comparing Irradiation Plus Long Term Adjuvant Androgen Deprivation With GnRH Antagonist Versus GnRH Agonist Plus Flare Protection in Patients With Very High Risk Localized or Locally Advanced Prostate Cancer (PEGASUS) Active, not recruiting ITA | GBR | FRA | ESP | DNK | DEU | CHE | BEL 0
NCT06501911 Phase I Bicalutamide A Study of Bicalutamide With Brain Re-irradiation to Treat Recurrent/Progressive High Grade Glioma Not yet recruiting USA 0
NCT02614859 Phase II Bicalutamide Metformin Bicalutamide With or Without Metformin for Biochemical Recurrence in Overweight or Obese Prostate Cancer Patients Completed USA 0
NCT02366494 Phase I Leuprolide Goserelin Triptorelin Bicalutamide Docetaxel Micro RNAs to Predict Response to Androgen Deprivation Therapy Active, not recruiting USA 0
NCT00002651 Phase III Bicalutamide Goserelin Hormone Therapy in Treating Men With Stage IV Prostate Cancer Completed CAN 0
NCT02531516 Phase III Abiraterone + Apalutamide + Prednisone Bicalutamide An Efficacy and Safety Study of JNJ-56021927 (ARN-509) in High-risk Prostate Cancer Subjects Receiving Primary Radiation Therapy Active, not recruiting USA | TUR | SWE | ROU | POL | NLD | ISR | GBR | FRA | ESP | DEU | CZE | CAN | BRA | BEL | ARG 7
NCT01674270 Phase II Bicalutamide Degarelix Degarelix Neo-Adjuvant Radical Prostatectomy Trial Completed CAN 0
NCT02064036 Phase I Bicalutamide Goserelin Leuprolide Stereotactic Boost and Long-Term Androgen Deprivation for Adenocarcinoma of the Prostate Completed USA 0
NCT01809691 Phase III Orteronel Bicalutamide S1216, Phase III ADT+TAK-700 vs. ADT+Bicalutamide for Metastatic Prostate Cancer Active, not recruiting USA 0
NCT00936390 Phase III Flutamide Goserelin Leuprolide Triptorelin Bicalutamide Radiation Therapy With or Without Androgen-Deprivation Therapy in Treating Patients With Prostate Cancer Active, not recruiting USA | CAN 0
NCT05327647 Phase II Bicalutamide A Phase II Trial of Bicalutamide in Patients Receiving Intravesical BCG for Non-muscle Invasive Bladder Cancer (BicaBCa) Recruiting CAN 0
NCT04025372 Phase II Bicalutamide Darolutamide INTREPId (INTermediate Risk Erection PreservatIon Trial) Active, not recruiting USA 0
NCT03458221 Phase II Itraconazole Everolimus Letrozole Bicalutamide Signal TrAnsduction Pathway Activity Analysis in OVarian cancER (STAPOVER) Recruiting NLD 0
NCT02346253 Phase Ib/II Leuprolide Triptorelin Degarelix Bicalutamide Goserelin High-Dose Brachytherapy in Treating Patients With Prostate Cancer Active, not recruiting USA 0
NCT03809000 Phase II Goserelin Bicalutamide Enzalutamide Leuprolide A Trial to See What the Results Are for Radiation Therapy and Hormone Therapy vs Radiation Therapy With Enhanced Hormone Therapy With Enzalutamide for Patients With PSA Recurrence After Surgery (STEEL) Active, not recruiting USA | CAN 0
NCT01342367 Phase I Bicalutamide Dutasteride Finasteride Feasibility of Hormones and Radiation for Intermediate or High Risk Prostate Cancer Active, not recruiting USA 0


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