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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
Bicalutamide	Casodex		Hormone - Anti-androgens 57	Casodex (bicalutamide) is an androgen-receptor antagonist that binds androgen receptors and inhibits androgen binding, therefore inhibits AR-dependent growth of tumor cells (PMID: 9428389). Casodex (bicalutamide) is approved, in combination with a luteinizing hormone-releasing hormone (LHRH) analog, for metastatic carcinoma of the prostate (FDA.gov).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
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Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT00936390	Phase III	Flutamide Goserelin Leuprolide Triptorelin Bicalutamide	Radiation Therapy With or Without Androgen-Deprivation Therapy in Treating Patients With Prostate Cancer	Active, not recruiting	USA \| CAN	0
NCT01342367	Phase I	Bicalutamide Dutasteride Finasteride	Feasibility of Hormones and Radiation for Intermediate or High Risk Prostate Cancer	Active, not recruiting	USA	0
NCT01809691	Phase III	Orteronel Bicalutamide	S1216, Phase III ADT+TAK-700 vs. ADT+Bicalutamide for Metastatic Prostate Cancer	Active, not recruiting	USA	0
NCT02346253	Phase Ib/II	Leuprolide Triptorelin Degarelix Bicalutamide Goserelin	High-Dose Brachytherapy in Treating Patients With Prostate Cancer	Active, not recruiting	USA	0
NCT02531516	Phase III	Abiraterone + Apalutamide + Prednisone Bicalutamide	An Efficacy and Safety Study of JNJ-56021927 (ARN-509) in High-risk Prostate Cancer Subjects Receiving Primary Radiation Therapy	Active, not recruiting	USA \| TUR \| SWE \| ROU \| POL \| NLD \| ISR \| GBR \| FRA \| ESP \| DEU \| CZE \| CAN \| BRA \| BEL \| ARG	7
NCT02799706	Phase III	Flutamide Degarelix Bicalutamide	Trial Comparing Irradiation Plus Long Term Adjuvant Androgen Deprivation With GnRH Antagonist Versus GnRH Agonist Plus Flare Protection in Patients With Very High Risk Localized or Locally Advanced Prostate Cancer (PEGASUS)	Active, not recruiting	ITA \| GBR \| FRA \| ESP \| DNK \| DEU \| CHE \| BEL	0
NCT03809000	Phase II	Goserelin Bicalutamide Enzalutamide Leuprolide	A Trial to See What the Results Are for Radiation Therapy and Hormone Therapy vs Radiation Therapy With Enhanced Hormone Therapy With Enzalutamide for Patients With PSA Recurrence After Surgery (STEEL)	Active, not recruiting	USA \| CAN	0
NCT04025372	Phase II	Bicalutamide Darolutamide	INTREPId (INTermediate Risk Erection PreservatIon Trial)	Active, not recruiting	USA	0
NCT00002651	Phase III	Bicalutamide Goserelin	Hormone Therapy in Treating Men With Stage IV Prostate Cancer	Completed	CAN	0
NCT00541047	Phase III	Leuprolide Goserelin Bicalutamide	Radiation Therapy and Androgen Deprivation Therapy in Treating Patients Who Have Undergone Surgery for Prostate Cancer (RADICALS)	Completed	GBR \| CAN	0
NCT01420250	Phase I	Bicalutamide Cabazitaxel	Cabazitaxel With Radiation and Hormone Therapy for Prostate Cancer	Completed	USA	0
NCT01674270	Phase II	Bicalutamide Degarelix	Degarelix Neo-Adjuvant Radical Prostatectomy Trial	Completed	CAN	0
NCT02058706	Phase II	Goserelin Bicalutamide Enzalutamide Leuprolide	LHRH Analogue Therapy With Enzalutamide or Bicalutamide in Treating Patients With Metastatic Hormone Sensitive Prostate Cancer	Completed	USA	0
NCT02059213	Phase II	Goserelin Palbociclib Bicalutamide Leuprolide	A Phase II Study of Androgen Deprivation Therapy With or Without PD 0332991 in RB-Positive Metastatic Prostate Cancer	Completed	USA	0
NCT02064036	Phase I	Bicalutamide Goserelin Leuprolide	Stereotactic Boost and Long-Term Androgen Deprivation for Adenocarcinoma of the Prostate	Completed	USA	0
NCT02366494	Phase I	Leuprolide Goserelin Triptorelin Bicalutamide Docetaxel	Micro RNAs to Predict Response to Androgen Deprivation Therapy	Completed	USA	0
NCT02614859	Phase II	Bicalutamide Metformin	Bicalutamide With or Without Metformin for Biochemical Recurrence in Overweight or Obese Prostate Cancer Patients	Completed	USA	0
NCT06501911	Phase I	Bicalutamide	A Study of Bicalutamide With Brain Re-irradiation to Treat Recurrent/Progressive High Grade Glioma	Not yet recruiting	USA	0
NCT03458221	Phase II	Itraconazole Everolimus Letrozole Bicalutamide	Signal TrAnsduction Pathway Activity Analysis in OVarian cancER (STAPOVER)	Recruiting	NLD	0
NCT03678025	Phase III	Docetaxel Nilutamide Triptorelin Bicalutamide Leuprolide Degarelix Goserelin Flutamide Prednisone Abiraterone Histrelin acetate	Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer	Recruiting	USA \| CHE	3
NCT04787744	Phase II	Goserelin Degarelix Relugolix Nilutamide Triptorelin Histrelin acetate Docetaxel + Prednisone Leuprolide Apalutamide Abiraterone + Prednisone Flutamide Abiraterone + Methylprednisolone Bicalutamide Docetaxel Enzalutamide	Veterans Affairs Seamless Phase II/III Randomized Trial of STAndard Systemic theRapy With or Without PET-directed Local Therapy for Oligometastatic pRosTate Cancer (VA STARPORT)	Recruiting	USA	0
NCT05050084	Phase III	Buserelin Relugolix Degarelix Goserelin Leuprolide Histrelin acetate Triptorelin Darolutamide + Goserelin Bicalutamide Darolutamide + Degarelix Darolutamide + Leuprolide Darolutamide + Triptorelin Buserelin + Darolutamide Darolutamide + Histrelin acetate Flutamide Darolutamide + Relugolix	Two Studies for Patients With Unfavorable Intermediate Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a Higher Gene Risk Score	Recruiting	USA \| CAN	0
NCT05327647	Phase II	Bicalutamide	A Phase II Trial of Bicalutamide in Patients Receiving Intravesical BCG for Non-muscle Invasive Bladder Cancer (BicaBCa)	Recruiting	CAN	0
NCT02582749	Phase II	Bicalutamide + Radium Ra 223 dichloride Bicalutamide	Androgen Deprivation Therapy +/- Radium-223 Dichloride in Metastatic Prostate Cancer With Bone Metastases	Terminated	USA	0
NCT03147196	Phase II	Bicalutamide + Raloxifene Raloxifene Bicalutamide	Bicalutamide and Raloxifene Hydrochloride in Treating Patients With Prostate Cancer Undergoing Surgery	Withdrawn		0
NCT06018116	Phase II	Bicalutamide	A Canadian Phase II Trial of Bicalutamide in Patients Receiving Maintenance Avelumab for Metastatic Urothelial Cancer (CANUCK-01)	Withdrawn	CAN	0

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