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| ID | DOID:0080705 |
| Name | medulloblastoma SHH activated and TP53 wild-type |
| Definition | A medulloblastoma SHH activated that is characterized as a molecular subtype by activation of the sonic hedgehog (SHH) pathway and the absence of TP53 mutations. |
| Source | DiseaseOntology.org |
| Alt Ids | |
| Path | disease disease of cellular proliferation cancer organ system cancer nervous system cancer central nervous system cancer brain cancer infratentorial cancer medulloblastoma medulloblastoma SHH activated medulloblastoma SHH activated and TP53 wild-type |
| Molecular Profile | Therapy | Indication/Tumor Type | Response Type | Profile Response Detail |
|---|
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04402073 | Phase II | Cisplatin + Lomustine + Vincristine Sulfate Cisplatin + Lomustine + Sonidegib + Vincristine Sulfate | Personalized Risk-Adapted Therapy in Post-Pubertal Patients With Newly-Diagnosed Medulloblastoma (PersoMed-I) | Terminated | NLD | ITA | FRA | ESP | DEU | CHE | AUT | AUS | 0 |