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| ID | DOID:9513 |
| Name | plasma cell leukemia |
| Definition | A plasma cell neoplasm that is characterized by the presence of a circulating clonal plasma cell count that exceeds 2x10^9/L or is 20% of the leukocyte differential count. |
| Source | DiseaseOntology.org |
| Alt Ids | |
| Path | disease disease of cellular proliferation cancer organ system cancer hematologic cancer lymphoma non-Hodgkin lymphoma B-cell lymphoma mature B-cell neoplasm plasma cell neoplasm plasma cell leukemia |
| Molecular Profile | Therapy | Indication/Tumor Type | Response Type | Profile Response Detail |
|---|
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03441958 | Phase Ib/II | Cyclophosphamide + ECT-001 cord blood cells + Fludarabine + Mycophenolate mofetil + Tacrolimus | ECT-001 (UM171) Expanded Cord Blood Transplant to Treat High-risk Multiple Myeloma | Active, not recruiting | CAN | 0 |
| NCT05208307 | Phase II | Belantamab mafodotin-blmf + Dexamethasone + Pomalidomide | Belantamab Mafodotin, Pomalidomide and Dexamethasone for the Treatment of High-Risk Myeloma | Recruiting | USA | 0 |
| NCT05823571 | Phase I | Itacitinib | Itacitinib With High-dose Posttransplantation Cyclophosphamide in Older Patients | Active, not recruiting | USA | 0 |
| NCT06066359 | Phase Ib/II | Cyclophosphamide + Fludarabine + NY-ESO-1 TCR/IL-15 NK cells | Phase I/II Trial of Cord Blood-Derived NK Cells Genetically Engineered With NY-ESO-1 TCR/IL-15 Cell Receptor for Relapsed/Refractory Multiple Myeloma | Recruiting | USA | 0 |
| NCT06517017 | Phase II | Dexamethasone + Isatuximab + Lenalidomide | Use of Isatuximab, Dexamethasone and Lenalidomide in a Go-Slow Fashion for Ultra-Frail Patients With Multiple Myeloma (UltraFrailMM) | Recruiting | USA | 0 |
| NCT06636552 | Phase II | Daratumumab Bortezomib + Cyclophosphamide + Daratumumab + Dexamethasone | An Investigator-Initiated, Phase II, Multicenter, Open-Label, Single-Arm, Prospective Clinical Trial to Evaluate the Efficacy and Safety of Alternating Bortezomib-Based Regimens in Combination With DaratUMumab Followed by Maintenance With Daratumumab in the Frontline Setting of Primary Plasma CEll L (EUMELEIA) | Recruiting | GRC | 0 |
| NCT06830733 | Phase II | ARI0002h | Study to Evaluate the Safety and Efficacy of ARI0002h, for the Initial Treatment of Patients With Primary Plasma Cell Leukaemia (GEM-PLASMACAR) | Not yet recruiting | ESP | 0 |