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| Drug Name | NG-641 |
| Trade Name | |
| Synonyms | NG 641|NG641 |
| Drug Descriptions |
NG-641 is an engineered oncolytic enadenotucirev adenovirus expressing a bispecific FAP-TAc T-cell activator that binds to fibroblast activating protein (FAP) on cancer associated fibroblasts and to CD3 on T-lymphocytes, as well as CXCL9, CXCL10, and IFN alpha, which potentially enhances T-cell activation and induces killing of FAP-positive tumor fibroblasts (Cancer Res 2019;79(13 Suppl):Abstract nr 5013). |
| DrugClasses | |
| CAS Registry Number | NA |
| NCIT ID | C168790 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| NG-641 | NG-641 | 0 | 2 |
| NG-641 + Nivolumab | NG-641 Nivolumab | 0 | 1 |
| NG-641 + Pembrolizumab | NG-641 Pembrolizumab | 0 | 1 |
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