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Drug Name | siG12D-LODER |
Trade Name | |
Synonyms | siG12D LODER |
Drug Descriptions |
siG12D-LODER is a biodegradable polymer containing KRAS G12D targeting siRNA (siG12D), which slowly releases siG12D in the tumor after implantation, potentially inducing apoptosis and inhibiting cell migration, and reducing metastasis (PMID: 26009994). |
DrugClasses | |
CAS Registry Number | NA |
NCIT ID | C95772 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Erlotinib + Gemcitabine + Oxaliplatin + siG12D-LODER | Erlotinib Gemcitabine Oxaliplatin siG12D-LODER | 0 | 0 |
Fluorouracil + Irinotecan + Oxaliplatin + siG12D-LODER | Fluorouracil Irinotecan Oxaliplatin siG12D-LODER | 0 | 0 |
Gemcitabine + Nab-paclitaxel + siG12D-LODER | Gemcitabine Nab-paclitaxel siG12D-LODER | 0 | 1 |
Gemcitabine + siG12D-LODER | Gemcitabine siG12D-LODER | 0 | 0 |
siG12D-LODER | siG12D-LODER | 0 | 0 |