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Drug Name | MKC-3946 |
Trade Name | |
Synonyms | MKC 3946|MKC3946 |
Drug Descriptions |
MKC-3946 is small molecule drug that targets the endoribonuclease domain of Ire1 alpha (ERN1) and inhibits XBP1 splicing, potentially resulting in increased apoptosis and decreased tumor growth (PMID: 22538852). |
DrugClasses | |
CAS Registry Number | 1093119-54-0 |
NCIT ID | NA |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
BMI-135 + MKC-3946 | BMI-135 MKC-3946 | 0 | 0 |
Bortezomib + MKC-3946 | Bortezomib MKC-3946 | 0 | 0 |
MKC-3946 | MKC-3946 | 0 | 0 |
MKC-3946 + Tanespimycin | MKC-3946 Tanespimycin | 0 | 0 |