Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Drug Name | HC-1119 |
Trade Name | |
Synonyms | HC 1119|HC1119|D3-ENT|Deuterated Enzalutamide|N-trideuteromethyl Enzalutamide |
Drug Descriptions |
HC-1119 is a deuterated version of enzalutamide that inhibits androgen receptor (AR) by blocking its nuclear translocation and DNA-binding activity, which potentially results in enhanced apoptosis and reduced growth of AR expressing tumor cells (Journal of Clinical Oncology 2018 36:15_suppl, e17021; NCI Drug Dictionary). |
DrugClasses | Hormone - Anti-androgens 54 |
CAS Registry Number | 1443331-82-5 |
NCIT ID | C158096 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
HC-1119 | HC-1119 | 0 | 1 |