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Therapy Name HC-1119
Synonyms
Therapy Description

HC-1119 is a deuterated version of enzalutamide that inhibits androgen receptor (AR) by blocking its nuclear translocation and DNA-binding activity, which potentially results in enhanced apoptosis and reduced growth of AR expressing tumor cells (Journal of Clinical Oncology 2018 36:15_suppl, e17021; NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
HC-1119 HC 1119|HC1119|D3-ENT|Deuterated Enzalutamide|N-trideuteromethyl Enzalutamide Hormone - Anti-androgens 54 HC-1119 is a deuterated version of enzalutamide that inhibits androgen receptor (AR) by blocking its nuclear translocation and DNA-binding activity, which potentially results in enhanced apoptosis and reduced growth of AR expressing tumor cells (Journal of Clinical Oncology 2018 36:15_suppl, e17021; NCI Drug Dictionary).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03850795 Phase III Enzalutamide HC-1119 HC-1119 Versus Enzalutamide in Metastatic Castration-Resistant Prostate Cancer (mCRPC) Terminated USA | POL | NLD | ITA | GBR | FRA | FIN | ESP | DNK | DEU | CAN | AUT | AUS 1


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