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Drug Name E7777
Trade Name
Synonyms E-7777|E 7777
Drug Descriptions

E7777 is a recombinant protein consisting of the binding domain of the cytokine IL-2 fused to fragments A and B of the diphtheria toxin, which binds to the IL-2 receptor on tumor cells, and following endocytosis leads to inhibition of protein synthesis, potentially resulting in cell death (PMID: 33792128, NCI Thesaurus).

DrugClasses
CAS Registry Number NA
NCIT ID C126273

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Therapy Name Drugs Efficacy Evidence Clinical Trials
E7777 E7777 0 2
E7777 + Pembrolizumab E7777 Pembrolizumab 0 1


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