THIO
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| Drug Name | THIO |
| Trade Name | |
| Synonyms | 6-thio-2'-deoxyguanosine|6-thio-dG |
| Drug Descriptions |
THIO (6-thio-2'-deoxyguanosine) is precursor nucleoside analogue that incorporates into newly synthesized telomeres, leading to telomere dysfunction and apoptosis in telomerase-positive cells, and potential anti-tumor activity (PMID: 34593527; PMID: 25516420). |
| DrugClasses | |
| CAS Registry Number | NA |
| NCIT ID | NA |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Cemiplimab + THIO | Cemiplimab THIO | 0 | 1 |
| Radiotherapy + Temozolomide + THIO | Radiotherapy THIO Temozolomide | 0 | 0 |
| Radiotherapy + THIO | Radiotherapy THIO | 0 | 0 |
| THIO | THIO | 0 | 0 |
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