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Drug Name | TPX-4589 |
Trade Name | |
Synonyms | LM 302|LM302|LM-302|TPX 4589|TPX4589 |
Drug Descriptions |
TPX-4589 (LM-302) is an antibody-drug conjugate (ADC) comprising a claudin 18.2 (CLDN18.2) targeted antibody linked to monomethyl auristatin E (MMAE), which potentially inhibits proliferation of CLDN18.2-expressing tumor cells and tumor growth (Eur J Cancer 2022 Vol 174, Supp 1:S41-S42). |
DrugClasses | CLDN18.2 Antibody 19 |
CAS Registry Number | NA |
NCIT ID | C185853 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Toripalimab-tpzi + TPX-4589 | TPX-4589 Toripalimab-tpzi | 0 | 1 |
TPX-4589 | TPX-4589 | 0 | 2 |