IBI343
Drug Detail
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| Drug Name | IBI343 |
| Trade Name | |
| Synonyms | IBI-343|IBI 343 |
| Drug Descriptions |
IBI343 is an antibody-drug conjugate (ADC) comprising an anti-Claudin18.2 (CLDN18.2) monoclonal antibody linked to the topoisomerase I inhibitor exatecan, which potentially induces apoptosis in tumor cells expressing CLDN18.2 and results in antitumor activity (J Clin Oncol 42, 2024 (suppl 16; abstr 3037), NCI Drug Dictionary). |
| DrugClasses | CLDN18.2 Antibody 23 |
| CAS Registry Number | NA |
| NCIT ID | C189808 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Fluorouracil + IBI343 + Irinotecan + Leucovorin + Oxaliplatin | Fluorouracil IBI343 Irinotecan Leucovorin Oxaliplatin | 0 | 1 |
| Fluorouracil + IBI343 + Leucovorin + Oxaliplatin | Fluorouracil IBI343 Leucovorin Oxaliplatin | 0 | 1 |
| IBI343 | IBI343 | 0 | 1 |
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