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Drug Name | SOT102 |
Trade Name | |
Synonyms | SOT-102|SOT 102|SO N102|SO-N102|SON102 |
Drug Descriptions |
SOT102 is an antibody-drug conjugate (ADC) comprising a claudin 18.2 (CLDN18.2)-targeted antibody linked to a derivative of the cytotoxic anthracycline PNU-159682, which potentially leads to impaired DNA replication and protein synthesis, resulting in killing of tumor cells expressing CLDN18.2 (NCI Drug Dictionary). |
DrugClasses | CLDN18.2 Antibody 19 |
CAS Registry Number | NA |
NCIT ID | C190788 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Fluorouracil + Leucovorin + Nivolumab + Oxaliplatin + SOT102 | Fluorouracil Leucovorin Nivolumab Oxaliplatin SOT102 | 0 | 1 |
Gemcitabine + Nab-paclitaxel + SOT102 | Gemcitabine Nab-paclitaxel SOT102 | 0 | 1 |
SOT102 | SOT102 | 0 | 1 |