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Therapy Name SOT102
Synonyms
Therapy Description

SOT102 is an antibody-drug conjugate (ADC) comprising a claudin 18.2 (CLDN18.2)-targeted antibody linked to a derivative of the cytotoxic anthracycline PNU-159682, which potentially leads to impaired DNA replication and protein synthesis, resulting in killing of tumor cells expressing CLDN18.2 (NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
SOT102 SOT-102|SOT 102|SO N102|SO-N102|SON102 CLDN18.2 Antibody 19 SOT102 is an antibody-drug conjugate (ADC) comprising a claudin 18.2 (CLDN18.2)-targeted antibody linked to a derivative of the cytotoxic anthracycline PNU-159682, which potentially leads to impaired DNA replication and protein synthesis, resulting in killing of tumor cells expressing CLDN18.2 (NCI Drug Dictionary).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05525286 Phase Ib/II Fluorouracil + Leucovorin + Nivolumab + Oxaliplatin + SOT102 Gemcitabine + Nab-paclitaxel + SOT102 SOT102 Clinical Trial of SOT102 Antibody Drug Conjugate in Patients With Advanced Gastric and Pancreatic Adenocarcinoma (CLAUDIO-01) Recruiting USA | FRA | ESP | CZE | BEL 0


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