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Drug Name | AB598 |
Trade Name | |
Synonyms | AB 598|AB-598 |
Drug Descriptions |
AB598 is an inhibitory monoclonal antibody against ENTPD1 (CD39), which blocks ATPase activity, leading to increased extracellular ATP and potential activation of the tumor microenvironment and inhibition of tumor growth (PMID: 38797955). |
DrugClasses | CD39 Antibody 5 |
CAS Registry Number | NA |
NCIT ID | C200795 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
AB598 | AB598 | 0 | 1 |
AB598 + Carboplatin + Pemetrexed Disodium + Zimberelimab | AB598 Carboplatin Pemetrexed Disodium Zimberelimab | 0 | 1 |
AB598 + Fluorouracil + Leucovorin + Oxaliplatin + Zimberelimab | AB598 Fluorouracil Leucovorin Oxaliplatin Zimberelimab | 0 | 1 |