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Drug Name VG161
Trade Name
Synonyms VG-161|VG 161
Drug Descriptions

VG161 is an oncolytic herpes simplex virus-1 (HSV-1) engineered to express IL-12, IL-15, IL15Ra, and a PD-L1 (CD274)/PD-1 blocking peptide, which may induce antitumor immune response and decrease tumor growth (PMID: 36042555).

DrugClasses
CAS Registry Number NA
NCIT ID C179675

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Gemcitabine + Nab-paclitaxel + VG161 Gemcitabine Nab-paclitaxel VG161 0 0
Nivolumab + VG161 Nivolumab VG161 0 1
unspecified PD-1 antibody + VG161 VG161 unspecified PD-1 antibody 0 0
VG161 VG161 0 1


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