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Drug Name | VG161 |
Trade Name | |
Synonyms | VG-161|VG 161 |
Drug Descriptions |
VG161 is an oncolytic herpes simplex virus-1 (HSV-1) engineered to express IL-12, IL-15, IL15Ra, and a PD-L1 (CD274)/PD-1 blocking peptide, which may induce antitumor immune response and decrease tumor growth (PMID: 36042555). |
DrugClasses | |
CAS Registry Number | NA |
NCIT ID | C179675 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Gemcitabine + Nab-paclitaxel + VG161 | Gemcitabine Nab-paclitaxel VG161 | 0 | 0 |
Nivolumab + VG161 | Nivolumab VG161 | 0 | 1 |
unspecified PD-1 antibody + VG161 | VG161 unspecified PD-1 antibody | 0 | 0 |
VG161 | VG161 | 0 | 1 |