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Therapy Name VG161
Synonyms
Therapy Description

VG161 is an oncolytic herpes simplex virus-1 (HSV-1) engineered to express IL-12, IL-15, IL15Ra, and a PD-L1 (CD274)/PD-1 blocking peptide, which may induce antitumor immune response and decrease tumor growth (PMID: 36042555).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
VG161 VG-161|VG 161 VG161 is an oncolytic herpes simplex virus-1 (HSV-1) engineered to express IL-12, IL-15, IL15Ra, and a PD-L1 (CD274)/PD-1 blocking peptide, which may induce antitumor immune response and decrease tumor growth (PMID: 36042555).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05223816 Phase II Nivolumab + VG161 VG161 An Open-Label, Multiple-Center, Phase IIa/IIb Clinical Trial to Evaluate the Efficacy, Safety and Tolerability of VG161 as Monotherapy and in Combination With Nivolumab for Treatment of Patients With Hepatocellular Carcinoma or Intrahepatic Cholangiocarcinoma Recruiting USA 0


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