E-SYNC T cells
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| Drug Name | E-SYNC T cells |
| Trade Name | |
| Synonyms | Anti-EGFRvIII synNotch Receptor-induced Anti-EphA2/IL-13Ralpha2 CAR-T Cells |
| Drug Descriptions |
E-SYNC T cells are autologous T cells engineered to express a modified Notch receptor that binds to EGFRvIII expressed on tumor cells and induces the expression of an anti-EphA2 and anti-IL13Ra2 chimeric antigen receptor (CAR), which potentially leads to selective killing of tumor cells expressing EphA2 or IL13Ra2 (PMID: 33910979, NCI Drug Dictionary). |
| DrugClasses | IL13RA2 Immune Cell Therapy 7 |
| CAS Registry Number | NA |
| NCIT ID | C203620 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| E-SYNC T cells | E-SYNC T cells | 0 | 1 |
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