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Therapy Name E-SYNC T cells
Synonyms
Therapy Description

E-SYNC T cells are autologous T cells engineered to express a modified Notch receptor that binds to EGFRvIII expressed on tumor cells and induces the expression of an anti-EphA2 and anti-IL13Ra2 chimeric antigen receptor (CAR), which potentially leads to selective killing of tumor cells expressing EphA2 or IL13Ra2 (PMID: 33910979, NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
E-SYNC T cells Anti-EGFRvIII synNotch Receptor-induced Anti-EphA2/IL-13Ralpha2 CAR-T Cells E-SYNC T cells are autologous T cells engineered to express a modified Notch receptor that binds to EGFRvIII expressed on tumor cells and induces the expression of an anti-EphA2 and anti-IL13Ra2 chimeric antigen receptor (CAR), which potentially leads to selective killing of tumor cells expressing EphA2 or IL13Ra2 (PMID: 33910979, NCI Drug Dictionary).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06186401 Phase I E-SYNC T cells Cyclophosphamide + Fludarabine Anti-EGFRvIII synNotch Receptor Induced Anti-EphA2/IL-13Ralpha2 CAR (E-SYNC) T Cells Recruiting USA 0


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